Literature DB >> 3514797

A comparison of primidone, propranolol, and placebo in essential tremor, using quantitative analysis.

W P Gorman, R Cooper, P Pocock, M J Campbell.   

Abstract

The effects of placebo, propranolol and primidone were compared in 14 patients with essential tremor in a double blind, randomised, crossover study. Objective measures of tremor were obtained using an accelerometer with subsequent spectral analysis. Both propranolol (p less than 0.01) and primidone (p less than 0.01) gave significant improvement in tremor, but there was no significant difference in improvement between these drugs. Patients with higher dominant frequencies of tremor tended to respond to both drugs, while those with lower frequencies improved on one or other. There was no differential effect between the drugs with the frequency of tremor.

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Year:  1986        PMID： 3514797      PMCID： PMC1028650          DOI： 10.1136/jnnp.49.1.64

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  12 in total

1.  Suppression of essential tremor by propranolol: correlation of effect with drug plasma levels and intensity of beta-adrenergic blockade.

Authors:  R G McAllister; W R Markesbery; R W Ware; S M Howell
Journal:  Ann Neurol       Date:  1977-02       Impact factor: 10.422

2.  Effect of the beta adrenergic blocking agent propranolol on essential tremor.

Authors:  M H Morgan; R L Hewer; R Cooper
Journal:  J Neurol Neurosurg Psychiatry       Date:  1973-08       Impact factor: 10.154

3.  Essential tremor.

Authors:  T A Larsen; D B Calne
Journal:  Clin Neuropharmacol       Date:  1983       Impact factor: 1.592

4.  Essential tremor in Rochester, Minnesota: a 45-year study.

Authors:  A H Rajput; K P Offord; C M Beard; L T Kurland
Journal:  J Neurol Neurosurg Psychiatry       Date:  1984-05       Impact factor: 10.154

5.  Primidone in essential tremor.

Authors:  L J Findley
Journal:  Br Med J (Clin Res Ed)       Date:  1982-11-13

6.  Double-blind controlled study of primidone in essential tremor: preliminary results.

Authors:  L J Findley; S Calzetti
Journal:  Br Med J (Clin Res Ed)       Date:  1982 Aug 28-Sep 4

7.  The control of essential tremor by propranolol.

Authors:  G F Winkler; R R Young
Journal:  Trans Am Neurol Assoc       Date:  1971

8.  Long-term therapy of essential tremor with propranolol.

Authors:  T J Murray
Journal:  Can Med Assoc J       Date:  1976-11-06       Impact factor: 8.262

9.  The response of essential tremor to propranolol: evaluation of clinical variables governing its efficacy on prolonged administration.

Authors:  S Calzetti; L J Findley; E Perucca; A Richens
Journal:  J Neurol Neurosurg Psychiatry       Date:  1983-05       Impact factor: 10.154

10.  Benign familial tremor treated with primidone.

Authors:  M D O'Brien; A R Upton; P A Toseland
Journal:  Br Med J (Clin Res Ed)       Date:  1981-01-17
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  22 in total

Review 1.  Differential diagnosis of common tremor syndromes.

Authors:  R Bhidayasiri
Journal:  Postgrad Med J       Date:  2005-12       Impact factor: 2.401

Review 2.  Pharmacotherapy of essential tremor : an overview of existing and upcoming agents.

Authors:  Kelly E Lyons; Rajesh Pahwa
Journal:  CNS Drugs       Date:  2008       Impact factor: 5.749

3.  Anti-Tremor Action of Subtype Selective Positive Allosteric Modulators of GABAA Receptors in a Rat Model of Essential Tremors.

Authors:  Dipak V Amrutkar; Tino Dyhring; Thomas A Jacobsen; Janus S Larsen; Karin Sandager-Nielsen
Journal:  Cerebellum       Date:  2020-04       Impact factor: 3.847

Review 4.  The clinical use of barbiturates in neurological disorders.

Authors:  M C Smith; B J Riskin
Journal:  Drugs       Date:  1991-09       Impact factor: 9.546

5.  Pharmacologic management of essential tremor.

Authors:  Mark Lees; Loren Regier; Brent Jensen
Journal:  Can Fam Physician       Date:  2010-03       Impact factor: 3.275

6.  A patient with tremor, part 2: from diagnosis to treatment.

Authors:  Hrishikesh Kumar; Mandar Jog
Journal:  CMAJ       Date:  2011-08-15       Impact factor: 8.262

Review 7.  Therapeutic uses of beta-adrenoceptor blocking drugs in the central nervous system in man.

Authors:  P Turner
Journal:  Postgrad Med J       Date:  1989-01       Impact factor: 2.401

Review 8.  Benefits and risks of pharmacological treatments for essential tremor.

Authors:  Kelly E Lyons; Rajesh Pahwa; Cynthia L Comella; Mahmood S Eisa; Rodger J Elble; Stanley Fahn; Joseph Jankovic; Jorge L Juncos; William C Koller; William G Ondo; Kapil D Sethi; Matthew B Stern; Caroline M Tanner; Ron Tintner; Ray L Watts
Journal:  Drug Saf       Date:  2003       Impact factor: 5.606

9.  Objective predictors of 'early tolerance' to ventral intermediate nucleus of thalamus deep brain stimulation in essential tremor patients.

Authors:  Shabbir Hussain Merchant; Sheng-Han Kuo; Yu Qiping; Linda Winfield; Guy McKhann; Sameer Sheth; Seth L Pullman; Blair Ford
Journal:  Clin Neurophysiol       Date:  2018-06-05       Impact factor: 3.708

10.  The disposition of primidone in elderly patients.

Authors:  C Martines; G Gatti; E Sasso; S Calzetti; E Perucca
Journal:  Br J Clin Pharmacol       Date:  1990-10       Impact factor: 4.335
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