Guangfeng Liu1, Liang Han2, Yao Lu2, Changguan Wang2, Lie Ma1, Pei Zhang2, Cong Liu2, Xinrong Lu2, Zhizhong Ma3,4,5. 1. Department of Ophthalmology, Life Science Park of Zhong Guancun, Peking University International Hospital, Chang Ping District, Life Park Road No. 1 , Beijing, 102206, China. 2. Department of Ophthalmology, Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Eye Centre, Peking University Third Hospital, Beijing, 100191, China. 3. Department of Ophthalmology, Life Science Park of Zhong Guancun, Peking University International Hospital, Chang Ping District, Life Park Road No. 1 , Beijing, 102206, China. puh3_YK@bjmu.edu.cn. 4. Department of Ophthalmology, Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Eye Centre, Peking University Third Hospital, Beijing, 100191, China. puh3_YK@bjmu.edu.cn. 5. Department of Ophthalmology, Peking University Third Hospital, Haidian District, No. 49, North Huayuan Road, Beijing, 100191, China. puh3_YK@bjmu.edu.cn.
Abstract
PURPOSE: To investigate the pathogenic features of the polypoidal lesions from the specimens of polypoidal choroidal vasculopathy extracted from human subjects. METHODS: Seven specimens of polypoidal lesions extracted from five eyes of six patients (mean age, 60.16 ± 10.41 years) of polypoidal choroidal vasculopathy were examined. The polypoidal lesions were obtained by surgical excision. Thereafter, a histopathological analysis of the specimens was performed. RESULTS: The polypoidal lesions were oval nodules located underneath the retinal pigment epithelium. A pathological study of the lesions revealed that Bruch's membrane schisis was observed in all specimens and they were all located in the Bruch's membrane. The Bruch's membrane schisis and serosanguineous materials constituted the main structure of the lesions in five of the seven specimens, with small vessels being observed in two specimens. One specimen was composed of two polypoidal lesions of different characteristics, and one specimen had a neovessel membrane complex with several polypoidal lesions. Inflammatory cells and blood vessels were observed in the polypoidal lesion of the specimen with neovessel membrane complex. CONCLUSION: Polypoidal lesions of polypoidal choroidal vasculopathy are abnormalities of the Bruch's membrane. The lesions are characterized by the Bruch's membrane schisis, which is filled with serosanguineous materials. The lesions are progressive and may contain inflammatory cells and blood vessels.
PURPOSE: To investigate the pathogenic features of the polypoidal lesions from the specimens of polypoidal choroidal vasculopathy extracted from human subjects. METHODS: Seven specimens of polypoidal lesions extracted from five eyes of six patients (mean age, 60.16 ± 10.41 years) of polypoidal choroidal vasculopathy were examined. The polypoidal lesions were obtained by surgical excision. Thereafter, a histopathological analysis of the specimens was performed. RESULTS: The polypoidal lesions were oval nodules located underneath the retinal pigment epithelium. A pathological study of the lesions revealed that Bruch's membrane schisis was observed in all specimens and they were all located in the Bruch's membrane. The Bruch's membrane schisis and serosanguineous materials constituted the main structure of the lesions in five of the seven specimens, with small vessels being observed in two specimens. One specimen was composed of two polypoidal lesions of different characteristics, and one specimen had a neovessel membrane complex with several polypoidal lesions. Inflammatory cells and blood vessels were observed in the polypoidal lesion of the specimen with neovessel membrane complex. CONCLUSION: Polypoidal lesions of polypoidal choroidal vasculopathy are abnormalities of the Bruch's membrane. The lesions are characterized by the Bruch's membrane schisis, which is filled with serosanguineous materials. The lesions are progressive and may contain inflammatory cells and blood vessels.
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