Jorge Luis Vélez-Páez1,2, Wendy Tercero-Martínez1, Glenda Jiménez-Alulima1, Johanna Navarrete-Domínguez1, Luis Cornejo-Loor1, Christian Castro-Bustamante1, Miguel Cabanillas-Lazo3,4, Joshuan J Barboza5,4, Alfonso J Rodriguez-Morales6,7,8,9. 1. Unidad de Cuidados Intensivos, Centro de Investigación Clínica, Hospital Pablo Arturo Suárez, Quito, Ecuador. 2. Facultad de Ciencias Médicas, Universidad Central del Ecuador, Quito, Ecuador. 3. Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Peru. 4. Tau-Relaped Group, Trujillo, Peru. 5. Escuela de Medicina, Universidad Señor de Sipán, Chiclayo, Peru. 6. Grupo de Investigación Biomedicina, Faculty of Medicine, Fundación Universitaria Autónoma de Las Americas, Pereira, Risaralda, Colombia. 7. Institución Universitaria Visión de las Américas, Pereira, Risaralda, Colombia. 8. School of Medicine, Universidad Privada Franz Tamayo, Cochabamba, Bolivia. 9. Faculty of Health Sciences, Universidad Cientifica del Sur, Lima, Peru.
Abstract
INTRODUCTION: Hospitalized COVID-19 patients are at risk of hospital infection. The neutrophil-to-lymphocyte ratio (NLR), lymphocyte-C-reactive protein ratio (LCR) and mean platelet volume (MPV) are established inflammation markers reflecting the systemic inflammatory response. The objective of this study was to evaluate the clinical characteristics of patients with COVID-19 and bacterial co-infections, as well as the correlation with NLR and MPV. METHODS: We assessed the role of the NLR and MPV in diagnosing bacterial infections in COVID-19 patients. The Wilcoxon test was used to compare the mean NLR and MPV between the diagnostic evaluation moments, while the Mann-Whitney test was used to compare NLR and MPV by sex and age. RESULTS: The NLR was compared three days before the culture and the day of taking the culture, observing significant differences (p=0.020). MPV three days before the culture and the day of the culture were compared, also observing significant differences (p=0.031). NLR and MPV were compared at the different evaluation times according to sex and age group, observing for the age group significant differences for the NLR three days before the culture (p=0.004). CONCLUSION: In our study, there were significant differences in NLR and MPV between the three days before culture and the day of culture. It is advisable to continue to enrol more patients in the study so that in the future, we can add results on the diagnostic accuracy of the NLR and MPV in the timely diagnosis of bacterial infection in patients with COVID-19.
INTRODUCTION: Hospitalized COVID-19 patients are at risk of hospital infection. The neutrophil-to-lymphocyte ratio (NLR), lymphocyte-C-reactive protein ratio (LCR) and mean platelet volume (MPV) are established inflammation markers reflecting the systemic inflammatory response. The objective of this study was to evaluate the clinical characteristics of patients with COVID-19 and bacterial co-infections, as well as the correlation with NLR and MPV. METHODS: We assessed the role of the NLR and MPV in diagnosing bacterial infections in COVID-19 patients. The Wilcoxon test was used to compare the mean NLR and MPV between the diagnostic evaluation moments, while the Mann-Whitney test was used to compare NLR and MPV by sex and age. RESULTS: The NLR was compared three days before the culture and the day of taking the culture, observing significant differences (p=0.020). MPV three days before the culture and the day of the culture were compared, also observing significant differences (p=0.031). NLR and MPV were compared at the different evaluation times according to sex and age group, observing for the age group significant differences for the NLR three days before the culture (p=0.004). CONCLUSION: In our study, there were significant differences in NLR and MPV between the three days before culture and the day of culture. It is advisable to continue to enrol more patients in the study so that in the future, we can add results on the diagnostic accuracy of the NLR and MPV in the timely diagnosis of bacterial infection in patients with COVID-19.
Authors: Leigh Smith; Sara M Karaba; Joe Amoah; George Jones; Robin K Avery; Kathryn Dzintars; Taylor Helsel; Sara E Cosgrove; Valeria Fabre Journal: Infect Control Hosp Epidemiol Date: 2021-04-13 Impact factor: 6.520
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