Delphine Rahib1,2, Béatrice Bercot3, Héloïse Delagreverie4, Audrey Gabassi4, Constance Delaugerre4, Hélène Salord5, Vinca Icard5, Than-Thuy Le Thi5, Benjamin Leveau5, Hacène Khiri6, Julien Digne6, Marie-Noëlle Didelot7, Amandine Pisoni7, Edouard Tuaillon7, Nathalie Lydié1, Stéphanie Vandentorren1,2. 1. 472516Santé Publique France, Saint Maurice, France. 2. Inserm, 243485Institut Pierre Louis d'Épidémiologie et de Santé Publique (IPLESP UMRS 1136), Université de Paris, Paris, France. 3. Service de Bactériologie, 55663Hôpital St Louis, APHP, Inserm UMR1137, IAME, Université de Paris, Paris, France. 4. Service de Virologie, 55663Hôpital St Louis, APHP, Inserm U944, Université de Paris, Paris, France. 5. Hôpital de La Croix-Rousse, Centre de Ressources Biologiques Nord, 26900Hospices Civils de Lyon, Lyon, France. 6. 576778Laboratoire Alphabio, Marseille, France. 7. Département de Bactériologie-Virologie, 26905CHU de Montpellier, UMR Inserm 1058, Université de Montpellier, Montpellier, France.
Abstract
BACKGROUND: Men who have sex with men are increasingly diagnosed with sexually transmitted infections (STI) in France. To address this situation, quarterly screening for HIV combined with hepatitis B (HBV) and hepatitis C (HCV), as well as annual screening for C.trachomatis (CT) and N.gonorrhoeae (NG) are recommended. The MemoDepistages program offered an at-home screening solution for these infections. This study describes the feasibility of this screening process, the rate of positive test results, and the factors associated with positivity. METHODS: Participants were recruited online. Laboratories verified the quantity and quality of the samples. Logistic regression was used to determine the associated factors for infection. RESULTS: Overall, 1556 out of 1908 (81.6%) blood samples were tested for at least HIV. A total of eight participants (0.5%) were newly diagnosed with HIV and four with HCV (0.3%). No new infection was confirmed for HBV. Overall positivity was 9.3% for CT and 9.6% for NG. The highest positivity was reported in rectal swabs for CT (7.3%) and in pharyngeal swabs for NG (7.2%). Factors associated with extragenital CT/NG were age under 30 years (for pharyngeal and rectal infections) and having at least 10 partners in the past 6 months (p<0.001) (for pharyngeal infections only). CONCLUSIONS: The self-sampling kit for multiple STIs can perform comprehensive tests and identify new infections in young people, especially in extragenital sites.
BACKGROUND: Men who have sex with men are increasingly diagnosed with sexually transmitted infections (STI) in France. To address this situation, quarterly screening for HIV combined with hepatitis B (HBV) and hepatitis C (HCV), as well as annual screening for C.trachomatis (CT) and N.gonorrhoeae (NG) are recommended. The MemoDepistages program offered an at-home screening solution for these infections. This study describes the feasibility of this screening process, the rate of positive test results, and the factors associated with positivity. METHODS: Participants were recruited online. Laboratories verified the quantity and quality of the samples. Logistic regression was used to determine the associated factors for infection. RESULTS: Overall, 1556 out of 1908 (81.6%) blood samples were tested for at least HIV. A total of eight participants (0.5%) were newly diagnosed with HIV and four with HCV (0.3%). No new infection was confirmed for HBV. Overall positivity was 9.3% for CT and 9.6% for NG. The highest positivity was reported in rectal swabs for CT (7.3%) and in pharyngeal swabs for NG (7.2%). Factors associated with extragenital CT/NG were age under 30 years (for pharyngeal and rectal infections) and having at least 10 partners in the past 6 months (p<0.001) (for pharyngeal infections only). CONCLUSIONS: The self-sampling kit for multiple STIs can perform comprehensive tests and identify new infections in young people, especially in extragenital sites.
Authors: Meena S Ramchandani; Anna Berzkalns; Chase A Cannon; Julia C Dombrowski; Negusse Ocbamichael; Christine M Khosropour; Lindley A Barbee; Matthew R Golden Journal: J Acquir Immune Defic Syndr Date: 2022-08-15 Impact factor: 3.771