James Crum1, Xian Zhang2, Adam Noah2, Antonia Hamilton3, Ilias Tachtsidis4, Paul W Burgess3, Joy Hirsch5. 1. Institute of Cognitive Neuroscience, University College London, London, United Kingdom. Electronic address: james.crum.16@ucl.ac.uk. 2. Brain Function Laboratory, Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut. 3. Institute of Cognitive Neuroscience, University College London, London, United Kingdom. 4. Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom. 5. Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom; Brain Function Laboratory, Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut; Department of Neuroscience, Yale School of Medicine, New Haven, Connecticut; Department of Comparative Medicine, Yale School of Medicine, New Haven, Connecticut.
Abstract
BACKGROUND: Conventional paradigms in clinical neuroscience tend to be constrained in terms of ecological validity, raising several challenges to studying the mechanisms mediating treatments and outcomes in clinical settings. Addressing these issues requires real-world neuroimaging techniques that are capable of continuously collecting data during free-flowing interpersonal interactions and that allow for experimental designs that are representative of the clinical situations in which they occur. METHODS: In this work, we developed a paradigm that fractionates the major components of human-to-human verbal interactions occurring in clinical situations and used functional near-infrared spectroscopy to assess the brain systems underlying clinician-client discourse (N = 30). RESULTS: Cross-brain neural coupling between people was significantly greater during clinical interactions compared with everyday life verbal communication, particularly between the prefrontal cortex (e.g., inferior frontal gyrus) and inferior parietal lobule (e.g., supramarginal gyrus). The clinical tasks revealed extensive increases in activity across the prefrontal cortex, especially in the rostral prefrontal cortex (area 10), during periods in which participants were required to silently reason about the dysfunctional cognitions of the other person. CONCLUSIONS: This work demonstrates a novel experimental approach to investigating the neural underpinnings of interpersonal interactions that typically occur in clinical settings, and its findings support the idea that particular prefrontal systems might be critical to cultivating mental health.
BACKGROUND: Conventional paradigms in clinical neuroscience tend to be constrained in terms of ecological validity, raising several challenges to studying the mechanisms mediating treatments and outcomes in clinical settings. Addressing these issues requires real-world neuroimaging techniques that are capable of continuously collecting data during free-flowing interpersonal interactions and that allow for experimental designs that are representative of the clinical situations in which they occur. METHODS: In this work, we developed a paradigm that fractionates the major components of human-to-human verbal interactions occurring in clinical situations and used functional near-infrared spectroscopy to assess the brain systems underlying clinician-client discourse (N = 30). RESULTS: Cross-brain neural coupling between people was significantly greater during clinical interactions compared with everyday life verbal communication, particularly between the prefrontal cortex (e.g., inferior frontal gyrus) and inferior parietal lobule (e.g., supramarginal gyrus). The clinical tasks revealed extensive increases in activity across the prefrontal cortex, especially in the rostral prefrontal cortex (area 10), during periods in which participants were required to silently reason about the dysfunctional cognitions of the other person. CONCLUSIONS: This work demonstrates a novel experimental approach to investigating the neural underpinnings of interpersonal interactions that typically occur in clinical settings, and its findings support the idea that particular prefrontal systems might be critical to cultivating mental health.
Authors: Emmanuelle Volle; Angela de Lacy Costello; Laure M Coates; Catrin McGuire; Karren Towgood; Sam Gilbert; Serge Kinkingnehun; Jane E McNeil; Richard Greenwood; Ben Papps; Martin van den Broeck; Paul W Burgess Journal: Cereb Cortex Date: 2011-11-17 Impact factor: 5.357
Authors: Artur Czeszumski; Sara Eustergerling; Anne Lang; David Menrath; Michael Gerstenberger; Susanne Schuberth; Felix Schreiber; Zadkiel Zuluaga Rendon; Peter König Journal: Front Hum Neurosci Date: 2020-02-28 Impact factor: 3.169
Authors: Lisa Cipolotti; Barbara Spanò; Colm Healy; Carina Tudor-Sfetea; Edgar Chan; Mark White; Francesca Biondo; John Duncan; Tim Shallice; Marco Bozzali Journal: Neuropsychologia Date: 2016-09-23 Impact factor: 3.139