Yi Chen1, Xiaojian Yuan2,3, Yonglin Li4, Shannan Wu4, Xuefeng Miao4, Junfei Gong4, Yuntao Huang4. 1. Department of Nosocomial Infection, Yiwu Maternity and Children Hospital, Jinhua, People's Republic of China. 2. Department of Pediatric Surgery, Jiaxing Maternity and Children Hospital, Jiaxing, 314000, Zhejiang, People's Republic of China. yuanxiaojian2021@126.com. 3. Department of Pediatric Surgery, Yiwu Maternity and Children Hospital, Jinhua, People's Republic of China. yuanxiaojian2021@126.com. 4. Department of Pediatric Surgery, Yiwu Maternity and Children Hospital, Jinhua, People's Republic of China.
Abstract
PURPOSE: Hirschsprung's disease (HD) is a rare occurrence in premature infants, and the exact prevalence varying across studies. Thus, we conducted this study to determine the prevalence of and clinical presentation of HD in preterm infants. METHODS: The PubMed, EmBase, and Cochrane library databases were searched for eligible studies throughout May 2021. The pooled incidence with 95% confidence interval (CI) was calculated using the random-effects model. RESULTS: Thirty studies involved 4,557 children with HD were included. The pooled proportion of HD patients who were preterm infants was 7% (95% CI 5-8%; P < 0.001); the sensitivity analysis indicated that the pooled prevalence of preterm infants with HD ranged from 5.0% to 5.6%. Moreover, the pooled incidence of abdominal distention in HD patients was 83% (P < 0.001), that of vomiting was 61% (P < 0.001), that of bilious vomiting was 54% (P < 0.001), that of delayed meconium passage was 48% (P < 0.001), that of constipation was 44% (P < 0.001), and that of enterocolitis was 13% (P < 0.001). CONCLUSIONS: This study reported the prevalence of HD patients who were preterm infants, and the most common presentations were abdominal distention, vomiting, bilious vomiting, delayed meconium passage, constipation, and enterocolitis.
PURPOSE: Hirschsprung's disease (HD) is a rare occurrence in premature infants, and the exact prevalence varying across studies. Thus, we conducted this study to determine the prevalence of and clinical presentation of HD in preterm infants. METHODS: The PubMed, EmBase, and Cochrane library databases were searched for eligible studies throughout May 2021. The pooled incidence with 95% confidence interval (CI) was calculated using the random-effects model. RESULTS: Thirty studies involved 4,557 children with HD were included. The pooled proportion of HD patients who were preterm infants was 7% (95% CI 5-8%; P < 0.001); the sensitivity analysis indicated that the pooled prevalence of preterm infants with HD ranged from 5.0% to 5.6%. Moreover, the pooled incidence of abdominal distention in HD patients was 83% (P < 0.001), that of vomiting was 61% (P < 0.001), that of bilious vomiting was 54% (P < 0.001), that of delayed meconium passage was 48% (P < 0.001), that of constipation was 44% (P < 0.001), and that of enterocolitis was 13% (P < 0.001). CONCLUSIONS: This study reported the prevalence of HD patients who were preterm infants, and the most common presentations were abdominal distention, vomiting, bilious vomiting, delayed meconium passage, constipation, and enterocolitis.
Authors: Giuseppe Martucciello; Alessio Pini Prato; Prem Puri; Alexander M Holschneider; William Meier-Ruge; Vincenzo Jasonni; Juan A Tovar; Jay L Grosfeld Journal: J Pediatr Surg Date: 2005-10 Impact factor: 2.545
Authors: Ashley Rebekah Allen; Angelica R Putnam; Angela P Presson; Chelsea McCarty Allen; Douglas C Barnhart; Michael D Rollins Journal: Eur J Pediatr Surg Date: 2018-08-01 Impact factor: 2.191