Literature DB >> 3514237

Recombinant interleukin 2 enhances spontaneous insulin-dependent diabetes in BB rats.

H Kolb, J Zielasek, U Treichel, G Freytag, M Wrann, U Kiesel.   

Abstract

Treatment of BB rats with recombinant interleukin 2 (IL2) enhanced the development of spontaneous diabetes in these animals. A dose of 20 micrograms IL 2/kg body weight was administered twice daily for 80 days starting at 42 days of age. The rate of diabetes was doubled after IL 2 administration (53% vs. 23%) and the onset of diabetes was found to be accelerated by a mean of 18 days. Histological analysis showed enhanced inflammation of islets and in addition interstitial pancreatis. It is concluded that IL 2 has a regulatory effect on spontaneous organ-specific autoimmunity.

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Year:  1986        PMID： 3514237     DOI： 10.1002/eji.1830160218

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  7 in total

Review 1.  The role of interleukin-1 in the pathogenesis of IDDM.

Authors:  T Mandrup-Poulsen
Journal:  Diabetologia       Date:  1996-09       Impact factor: 10.122

2.  Class I and II major histocompatibility complex gene product expression by a rat insulinoma cell line in vitro following exposure to gamma interferon.

Authors:  B Issa-Chergui; A Goldner-Sauvé; E Colle; G J Prud'homme; P H Lapchak; P H van der Meide; T A Seemayer
Journal:  Diabetologia       Date:  1988-09       Impact factor: 10.122

3.  The natural history of lymphocyte subsets infiltrating the pancreas of NOD mice.

Authors:  A Signore; P Pozzilli; E A Gale; D Andreani; P C Beverley
Journal:  Diabetologia       Date:  1989-05       Impact factor: 10.122

Review 4.  Cytokines and autoimmunity.

Authors:  M G Cavallo; P Pozzilli; R Thorpe
Journal:  Clin Exp Immunol       Date:  1994-04       Impact factor: 4.330

5.  Interleukin-2-dependent control of disease development in spontaneously diabetic BB rats.

Authors:  J Zielasek; V Burkart; P Naylor; A Goldstein; U Kiesel; H Kolb
Journal:  Immunology       Date:  1990-02       Impact factor: 7.397

6.  Class-II and IL2 receptor positive cells in the pancreas of NOD mice.

Authors:  A Signore; A Cooke; P Pozzilli; G Butcher; E Simpson; P C Beverley
Journal:  Diabetologia       Date:  1987-11       Impact factor: 10.122

7.  Functional Modulation of Regulatory T Cells by IL-2.

Authors:  Byung-In Moon; Tae Hun Kim; Ju-Young Seoh
Journal:  PLoS One       Date:  2015-11-03       Impact factor: 3.240
  7 in total

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