| Literature DB >> 35141834 |
Tiago Barcelos Valiatti1, Tatiane Silva Carvalho2, Fernanda Fernandes Santos3, Carolina Silva Nodari3, Rodrigo Cayô3,4, Juliana Thalita Paulino da Silva3, Cicileia Correia da Silva5, Jacqueline Andrade Ferreira5, Lorena Brandhuber Moura5, Levy Assis Dos Santos5, Ana Cristina Gales3.
Abstract
In Brazil, carbapenem-resistant A. baumannii (CRAB) is a critical pathogen showing high carbapenem resistance rates. Currently, there is little epidemiological data on A. baumannii isolated in the Northern Brazilian region. Herein, this study aimed to characterize the resistance mechanisms of CRAB isolates recovered from hospitalized patients in the state of Rondônia in 2019. Most of CRAB were considered as extensively drug-resistant, and some of them showed high MICs for minocycline. Only polymyxins showed a satisfactory activity. All isolates carried blaOXA-23 and were included in 14 distinct clusters, with the predominance of clonal group A (29%). The IC1 was the most frequent clonal group, followed by IC5 and IC4. Here, we firstly reported the epidemiological scenario of CRAB in the state of Rondônia, located in the Brazilian Amazon region. The high frequency of CRAB presenting XDR phenotype is of great concern, due to limited therapeutical options, especially in the actual pandemic scenario, in which we observed an overcrowding of ICU beds. Such results are essential to better characterize the epidemiology of CRAB in the entire Brazilian territory.Entities:
Keywords: Acinetobacter spp.; Carbapenemase; International clones; Non-fermenter bacilli; Northern region
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Year: 2022 PMID： 35141834 PMCID： PMC9151963 DOI： 10.1007/s42770-022-00706-4
Source DB: PubMed Journal: Braz J Microbiol ISSN： 1517-8382 Impact factor: 2.214