Literature DB >> 3514080

Cellular localization of the Ro/SS-A antigen.

E Lopez-Robles, R Herrera-Esparza, E Avalos-Diaz.   

Abstract

The cellular localization of the Ro/SS-A antigen was defined using indirect immunofluorescence and eight monospecific anti- Ro/SS-A antisera which were identified by immunoblotting. Several mammalian tissues were used as substrates. The Ro/SS-A antigen was located mainly in the nucleus of dog liver and Hep-2-cells, and anti-Ro sera had produced a speckled staining pattern. Cytoplasmic fluorescence appeared only in one serum. IgG was the predominant immunoglobulin with anti-Ro/SS-A activity; five sera had complement fixing activity. The sera absorption studies with partially purified Ro/SS-A antigen and the negativation of the ANA tests had confirmed the specificity of our findings.

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Year:  1986        PMID： 3514080     DOI： 10.1007/BF02030965

Source DB:  PubMed          Journal:  Clin Rheumatol        ISSN： 0770-3198            Impact factor:   2.980


  18 in total

1.  Autoantibodies and the spectrum of Sjögren's syndrome.

Authors:  M Martinez-Lavin; J H Vaughan; E M Tan
Journal:  Ann Intern Med       Date:  1979-08       Impact factor: 25.391

2.  Differentiation and characterization of autoantibodies and their antigens in Sjögren's syndrome.

Authors:  M A Alspaugh; N Talal; E M Tan
Journal:  Arthritis Rheum       Date:  1976 Mar-Apr

3.  Subacute cutaneous lupus erythematosus: a cutaneous marker for a distinct lupus erythematosus subset.

Authors:  R D Sontheimer; J R Thomas; J N Gilliam
Journal:  Arch Dermatol       Date:  1979-12

4.  Homozygous C2 deficiency, lupus erythematosus, and anti-Ro (SSA) antibodies.

Authors:  T T Provost; F C Arnett; M Reichlin
Journal:  Arthritis Rheum       Date:  1983-10

5.  A serological marker for neonatal lupus erythematosus.

Authors:  W L Weston; C Harmon; C Peebles; D Manchester; H L Franco; J C Huff; D A Norris
Journal:  Br J Dermatol       Date:  1982-10       Impact factor: 9.302

6.  The importance of tissue substrate in the SS-A/Ro antigen-antibody system.

Authors:  C E Harmon; J S Deng; C L Peebles; E M Tan
Journal:  Arthritis Rheum       Date:  1984-02

7.  Systemic lupus erythematosus in the elderly: clinical and serological characteristics.

Authors:  L J Catoggio; R P Skinner; G Smith; P J Maddison
Journal:  J Rheumatol       Date:  1984-04       Impact factor: 4.666

8.  Correlative histologic and serologic findings of sicca syndrome in patients with systemic lupus erythematosus.

Authors:  H M Moutsopoulos; J H Klippel; N Pavlidis; R O Wolf; J B Sweet; A D Steinberg; F C Chu; T M Tarpley
Journal:  Arthritis Rheum       Date:  1980-01

9.  Connective-tissue disease, antibodies to ribonucleoprotein, and congenital heart block.

Authors:  J S Scott; P J Maddison; P V Taylor; E Esscher; O Scott; R P Skinner
Journal:  N Engl J Med       Date:  1983-07-28       Impact factor: 91.245

10.  Ro small cytoplasmic ribonucleoproteins are a subclass of La ribonucleoproteins: further characterization of the Ro and La small ribonucleoproteins from uninfected mammalian cells.

Authors:  J P Hendrick; S L Wolin; J Rinke; M R Lerner; J A Steitz
Journal:  Mol Cell Biol       Date:  1981-12       Impact factor: 4.272
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  3 in total

1.  A human monoclonal autoantibody to a nucleolar structure.

Authors:  M F Gonzalez; I Wichmann; J Yelamos; J Melero; R Magariño; J Sanchez-Roman; A Nuñez-Roldan; B Sanchez
Journal:  Clin Exp Immunol       Date:  1992-05       Impact factor: 4.330

2.  Protein heterogeneity in the human Ro/SSA ribonucleoproteins. The 52- and 60-kD Ro/SSA autoantigens are encoded by separate genes.

Authors:  K Itoh; Y Itoh; M B Frank
Journal:  J Clin Invest       Date:  1991-01       Impact factor: 14.808

3.  Analysis of the intracellular localization and assembly of Ro ribonucleoprotein particles by microinjection into Xenopus laevis oocytes.

Authors:  F H Simons; G J Pruijn; W J van Venrooij
Journal:  J Cell Biol       Date:  1994-06       Impact factor: 10.539
  3 in total

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