Literature DB >> 35140175

Functional Precision Medicine: Putting Drugs on Patient Cancer Cells and Seeing What Happens.

Anthony Letai1.   

Abstract

For too long, assays exposing patient tumor cells to drugs to identify active therapies have been dismissed as ineffective. In this issue of Cancer Discovery, two groups independently demonstrate clinical utility of such functional precision medicine assays in hematologic malignancies.See related article by Kornauth et al., p. 372.See related article by Malani et al., p. 388. ©2022 American Association for Cancer Research.

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Year:  2022        PMID： 35140175      PMCID： PMC8852353          DOI： 10.1158/2159-8290.CD-21-1498

Source DB:  PubMed          Journal:  Cancer Discov        ISSN： 2159-8274            Impact factor:   38.272


  11 in total

1.  Initial sequencing and analysis of the human genome.

Authors:  E S Lander; L M Linton; B Birren; C Nusbaum; M C Zody; J Baldwin; K Devon; K Dewar; M Doyle; W FitzHugh; R Funke; D Gage; K Harris; A Heaford; J Howland; L Kann; J Lehoczky; R LeVine; P McEwan; K McKernan; J Meldrim; J P Mesirov; C Miranda; W Morris; J Naylor; C Raymond; M Rosetti; R Santos; A Sheridan; C Sougnez; Y Stange-Thomann; N Stojanovic; A Subramanian; D Wyman; J Rogers; J Sulston; R Ainscough; S Beck; D Bentley; J Burton; C Clee; N Carter; A Coulson; R Deadman; P Deloukas; A Dunham; I Dunham; R Durbin; L French; D Grafham; S Gregory; T Hubbard; S Humphray; A Hunt; M Jones; C Lloyd; A McMurray; L Matthews; S Mercer; S Milne; J C Mullikin; A Mungall; R Plumb; M Ross; R Shownkeen; S Sims; R H Waterston; R K Wilson; L W Hillier; J D McPherson; M A Marra; E R Mardis; L A Fulton; A T Chinwalla; K H Pepin; W R Gish; S L Chissoe; M C Wendl; K D Delehaunty; T L Miner; A Delehaunty; J B Kramer; L L Cook; R S Fulton; D L Johnson; P J Minx; S W Clifton; T Hawkins; E Branscomb; P Predki; P Richardson; S Wenning; T Slezak; N Doggett; J F Cheng; A Olsen; S Lucas; C Elkin; E Uberbacher; M Frazier; R A Gibbs; D M Muzny; S E Scherer; J B Bouck; E J Sodergren; K C Worley; C M Rives; J H Gorrell; M L Metzker; S L Naylor; R S Kucherlapati; D L Nelson; G M Weinstock; Y Sakaki; A Fujiyama; M Hattori; T Yada; A Toyoda; T Itoh; C Kawagoe; H Watanabe; Y Totoki; T Taylor; J Weissenbach; R Heilig; W Saurin; F Artiguenave; P Brottier; T Bruls; E Pelletier; C Robert; P Wincker; D R Smith; L Doucette-Stamm; M Rubenfield; K Weinstock; H M Lee; J Dubois; A Rosenthal; M Platzer; G Nyakatura; S Taudien; A Rump; H Yang; J Yu; J Wang; G Huang; J Gu; L Hood; L Rowen; A Madan; S Qin; R W Davis; N A Federspiel; A P Abola; M J Proctor; R M Myers; J Schmutz; M Dickson; J Grimwood; D R Cox; M V Olson; R Kaul; C Raymond; N Shimizu; K Kawasaki; S Minoshima; G A Evans; M Athanasiou; R Schultz; B A Roe; F Chen; H Pan; J Ramser; H Lehrach; R Reinhardt; W R McCombie; M de la Bastide; N Dedhia; H Blöcker; K Hornischer; G Nordsiek; R Agarwala; L Aravind; J A Bailey; A Bateman; S Batzoglou; E Birney; P Bork; D G Brown; C B Burge; L Cerutti; H C Chen; D Church; M Clamp; R R Copley; T Doerks; S R Eddy; E E Eichler; T S Furey; J Galagan; J G Gilbert; C Harmon; Y Hayashizaki; D Haussler; H Hermjakob; K Hokamp; W Jang; L S Johnson; T A Jones; S Kasif; A Kaspryzk; S Kennedy; W J Kent; P Kitts; E V Koonin; I Korf; D Kulp; D Lancet; T M Lowe; A McLysaght; T Mikkelsen; J V Moran; N Mulder; V J Pollara; C P Ponting; G Schuler; J Schultz; G Slater; A F Smit; E Stupka; J Szustakowki; D Thierry-Mieg; J Thierry-Mieg; L Wagner; J Wallis; R Wheeler; A Williams; Y I Wolf; K H Wolfe; S P Yang; R F Yeh; F Collins; M S Guyer; J Peterson; A Felsenfeld; K A Wetterstrand; A Patrinos; M J Morgan; P de Jong; J J Catanese; K Osoegawa; H Shizuya; S Choi; Y J Chen; J Szustakowki
Journal:  Nature       Date:  2001-02-15       Impact factor: 49.962

2.  Molecularly targeted drug combinations demonstrate selective effectiveness for myeloid- and lymphoid-derived hematologic malignancies.

Authors:  Stephen E Kurtz; Christopher A Eide; Andy Kaempf; Vishesh Khanna; Samantha L Savage; Angela Rofelty; Isabel English; Hibery Ho; Ravi Pandya; William J Bolosky; Hoifung Poon; Michael W Deininger; Robert Collins; Ronan T Swords; Justin Watts; Daniel A Pollyea; Bruno C Medeiros; Elie Traer; Cristina E Tognon; Motomi Mori; Brian J Druker; Jeffrey W Tyner
Journal:  Proc Natl Acad Sci U S A       Date:  2017-08-07       Impact factor: 11.205

3.  A critical appraisal of the "human tumor stem-cell assay".

Authors:  P Selby; R N Buick; I Tannock
Journal:  N Engl J Med       Date:  1983-01-20       Impact factor: 91.245

4.  Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia.

Authors:  B J Druker; M Talpaz; D J Resta; B Peng; E Buchdunger; J M Ford; N B Lydon; H Kantarjian; R Capdeville; S Ohno-Jones; C L Sawyers
Journal:  N Engl J Med       Date:  2001-04-05       Impact factor: 91.245

5.  Implementing a Functional Precision Medicine Tumor Board for Acute Myeloid Leukemia.

Authors:  Tero Aittokallio; Krister Wennerberg; Caroline A Heckman; Olli Kallioniemi; Kimmo Porkka; Disha Malani; Ashwini Kumar; Oscar Brück; Mika Kontro; Bhagwan Yadav; Monica Hellesøy; Heikki Kuusanmäki; Olli Dufva; Matti Kankainen; Samuli Eldfors; Swapnil Potdar; Jani Saarela; Laura Turunen; Alun Parsons; Imre Västrik; Katja Kivinen; Janna Saarela; Riikka Räty; Minna Lehto; Maija Wolf; Bjorn Tore Gjertsen; Satu Mustjoki
Journal:  Cancer Discov       Date:  2021-11-17       Impact factor: 39.397

6.  Functional Precision Medicine Provides Clinical Benefit in Advanced Aggressive Hematologic Cancers and Identifies Exceptional Responders.

Authors:  Christoph Kornauth; Tea Pemovska; Gregory I Vladimer; Ingrid Simonitsch-Klupp; Giulio Superti-Furga; Berend Snijder; Philipp B Staber; Günther Bayer; Michael Bergmann; Sandra Eder; Ruth Eichner; Martin Erl; Harald Esterbauer; Ruth Exner; Verena Felsleitner-Hauer; Maurizio Forte; Alexander Gaiger; Klaus Geissler; Hildegard T Greinix; Wolfgang Gstöttner; Marcus Hacker; Bernd Lorenz Hartmann; Alexander W Hauswirth; Tim Heinemann; Daniel Heintel; Mir Alireza Hoda; Georg Hopfinger; Ulrich Jaeger; Lukas Kazianka; Lukas Kenner; Barbara Kiesewetter; Nikolaus Krall; Gerhard Krajnik; Stefan Kubicek; Trang Le; Simone Lubowitzki; Marius E Mayerhoefer; Elisabeth Menschel; Olaf Merkel; Katsuhiro Miura; Leonhard Müllauer; Peter Neumeister; Thomas Noesslinger; Katharina Ocko; Leopold Öhler; Michael Panny; Alexander Pichler; Edit Porpaczy; Gerald W Prager; Markus Raderer; Robin Ristl; Reinhard Ruckser; Julius Salamon; Ana-Iris Schiefer; Ann-Sofie Schmolke; Ilse Schwarzinger; Edgar Selzer; Christian Sillaber; Cathrin Skrabs; Wolfgang R Sperr; Ismet Srndic; Renate Thalhammer; Peter Valent; Emiel van der Kouwe; Katrina Vanura; Stefan Vogt; Cora Waldstein; Dominik Wolf; Christoph C Zielinski; Niklas Zojer
Journal:  Cancer Discov       Date:  2021-10-11       Impact factor: 39.397

7.  American Society of Clinical Oncology Technology Assessment: chemotherapy sensitivity and resistance assays.

Authors:  Deborah Schrag; Harinder S Garewal; Harold J Burstein; David J Samson; Daniel D Von Hoff; Mark R Somerfield
Journal:  J Clin Oncol       Date:  2004-08-02       Impact factor: 44.544

8.  Kinase pathway dependence in primary human leukemias determined by rapid inhibitor screening.

Authors:  Jeffrey W Tyner; Wayne F Yang; Armand Bankhead; Guang Fan; Luke B Fletcher; Jade Bryant; Jason M Glover; Bill H Chang; Stephen E Spurgeon; William H Fleming; Tibor Kovacsovics; Jason R Gotlib; Stephen T Oh; Michael W Deininger; Christian Michel Zwaan; Monique L Den Boer; Marry M van den Heuvel-Eibrink; Thomas O'Hare; Brian J Druker; Marc M Loriaux
Journal:  Cancer Res       Date:  2012-10-18       Impact factor: 12.701

9.  Molecular Features of Cancers Exhibiting Exceptional Responses to Treatment.

Authors:  David A Wheeler; Naoko Takebe; Toshinori Hinoue; Katherine A Hoadley; Maria F Cardenas; Alina M Hamilton; Peter W Laird; Linghua Wang; Adrienne Johnson; Ninad Dewal; Vincent Miller; David Piñeyro; Manuel Castro de Moura; Manel Esteller; Hui Shen; Jean Claude Zenklusen; Roy Tarnuzzer; Lisa M McShane; James V Tricoli; Paul M Williams; Irina Lubensky; Geraldine O'Sullivan-Coyne; Elise C Kohn; Richard F Little; Jeffrey White; Shakun Malik; Lyndsay Harris; Carol Weil; Alice P Chen; Chris Karlovich; Brian Rodgers; Lalitha Shankar; Paula Jacobs; Tracy Nolan; Jianhong Hu; Donna M Muzny; Harshavardhan Doddapaneni; Viktoriya Korchina; Julie Gastier-Foster; Jay Bowen; Kristen Leraas; Elijah F Edmondson; James H Doroshow; Barbara A Conley; S Percy Ivy; Louis M Staudt
Journal:  Cancer Cell       Date:  2020-11-19       Impact factor: 31.743

10.  The Exceptional Responders Initiative: Feasibility of a National Cancer Institute Pilot Study.

Authors:  Barbara A Conley; Lou Staudt; Naoko Takebe; David A Wheeler; Linghua Wang; Maria F Cardenas; Viktoriya Korchina; Jean Claude Zenklusen; Lisa M McShane; James V Tricoli; Paul M Williams; Irina Lubensky; Geraldine O'Sullivan-Coyne; Elise Kohn; Richard F Little; Jeffrey White; Shakun Malik; Lyndsay N Harris; Bhupinder Mann; Carol Weil; Roy Tarnuzzer; Chris Karlovich; Brian Rodgers; Lalitha Shankar; Paula M Jacobs; Tracy Nolan; Sean M Berryman; Julie Gastier-Foster; Jay Bowen; Kristen Leraas; Hui Shen; Peter W Laird; Manel Esteller; Vincent Miller; Adrienne Johnson; Elijah F Edmondson; Thomas J Giordano; Benjamin Kim; S Percy Ivy
Journal:  J Natl Cancer Inst       Date:  2021-01-04       Impact factor: 11.816
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