Literature DB >> 35139354

Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia.

Stefanie Kreutmair, Susanne Unger, Nicolás Gonzalo Núñez, Florian Ingelfinger, Chiara Alberti, Donatella De Feo, Sinduya Krishnarajah, Manuel Kauffmann, Ekaterina Friebel, Sepideh Babaei, Benjamin Gaborit, Mirjam Lutz, Nicole Puertas Jurado, Nisar P Malek, Siri Goepel, Peter Rosenberger, Helene A Häberle, Ikram Ayoub, Sally Al-Hajj, Jakob Nilsson, Manfred Claassen, Roland Liblau, Guillaume Martin-Blondel, Michael Bitzer, Antoine Roquilly, Burkhard Becher.   

Abstract

Entities:  

Year:  2022        PMID: 35139354      PMCID: PMC8822770          DOI: 10.1016/j.immuni.2022.01.015

Source DB:  PubMed          Journal:  Immunity        ISSN: 1074-7613            Impact factor:   31.745


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(Immunity 54, 1578–1593.e1–e5; July 13, 2021) In our original article, the FlowSOM-generated CD3+CD56+CD4−CD8− T cell cluster was named NKT cells. CD3+CD56+ cells do not exclusively describe NKT cells, but rather a heterogeneous collection of unconventional T cells. As we had not included iNKT-specific CD1d tetramers loaded with α-galactosylceramide in our panels, to be more precise, we corrected the term NKT cells with CD56+ T cells throughout the text and in the listed figures, as well as Tables S1, S3, and S4 and the graphical abstract. This error does not affect the overall conclusions of the paper. Additionally, to more appropriately reflect this change, reference Zhang et al., 2020a has been replaced with Notarbartolo et al., 2021.The authors apologize for any confusion caused. Shared T cell features between severe pathogen-induced RSs highlight the emergence of hyperinflammatory and exhausted subsets in COVID-19s (original) Shared T cell features between severe pathogen-induced RSs highlight the emergence of hyperinflammatory and exhausted subsets in COVID-19s (corrected) Distinct signatures of COVID-19s are exclusive to the lymphocyte compartment (original) Distinct signatures of COVID-19s are exclusive to the lymphocyte compartment (corrected) HLA profile links COVID-19 immunopathology to impaired virus recognition (original) HLA profile links COVID-19 immunopathology to impaired virus recognition (corrected) ACE2 expression in a CD4+ T cell subset increases after ex vivo stimulation (original) ACE2 expression in a CD4+ T cell subset increases after ex vivo stimulation (corrected) (original) (corrected) (original) (corrected)
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1.  Integrated longitudinal immunophenotypic, transcriptional and repertoire analyses delineate immune responses in COVID-19 patients.

Authors:  Samuele Notarbartolo; Valeria Ranzani; Alessandra Bandera; Paola Gruarin; Valeria Bevilacqua; Anna Rita Putignano; Andrea Gobbini; Eugenia Galeota; Cristina Manara; Mauro Bombaci; Elisa Pesce; Elena Zagato; Andrea Favalli; Maria Lucia Sarnicola; Serena Curti; Mariacristina Crosti; Martina Martinovic; Tanya Fabbris; Federico Marini; Lorena Donnici; Mariangela Lorenzo; Marilena Mancino; Riccardo Ungaro; Andrea Lombardi; Davide Mangioni; Antonio Muscatello; Stefano Aliberti; Francesco Blasi; Tullia De Feo; Daniele Prati; Lara Manganaro; Francesca Granucci; Antonio Lanzavecchia; Raffaele De Francesco; Andrea Gori; Renata Grifantini; Sergio Abrignani
Journal:  Sci Immunol       Date:  2021-08-10
  1 in total

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