Literature DB >> 351386

The mutagenic screening of fourteen imidazo compounds using a modified Ames' test.

J V Turner, A D Ward, C G Freeman.   

Abstract

Eight imidazo[1,2-alpha] pyrimidine derivatives and six cyclic guanidine derivatives were synthesized in order to study their physiological activity. Mutagenic effects were not detected with any compound in a modified Ames' Salmonella test using TA100, TA98, and TA1537, with or without S9. No inhibition of growth was observed with any test compound. Positive and negative controls behaved as expected.

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Year:  1978        PMID: 351386     DOI: 10.1016/0027-5107(78)90260-9

Source DB:  PubMed          Journal:  Mutat Res        ISSN: 0027-5107            Impact factor:   2.433


  2 in total

1.  The pseudo-Michael reaction of 1-aryl-4,5-dihydro-1H-imidazol-2-amines with ethyl ethoxymethylenecyanoacetate.

Authors:  Agnieszka A Kaczor; Urszula Kijkowska-Murak; Kalevi Pihlaja; Jari Sinkkonen; Waldemar Wysocki; Zbigniew Karczmarzyk; Dariusz Matosiuk
Journal:  Monatsh Chem       Date:  2013-05-14       Impact factor: 1.451

2.  Synthesis, central nervous system activity, and structure-activity relationship of 1-aryl-6-benzyl-7-hydroxy-2,3-dihydroimidazo[1,2-a]pyrimidine-5(1H)-ones.

Authors:  Marzena Rządkowska; Elżbieta Szacoń; Agnieszka A Kaczor; Sylwia Fidecka; Ewa Kędzierska; Dariusz Matosiuk
Journal:  Med Chem Res       Date:  2014-03-27       Impact factor: 1.965

  2 in total

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