| Literature DB >> 35138108 |
Xingxing Li1,2, Jie Fu1,2, Yihua Li1, Jiachang Liu1,2, Rongmei Gao1, Yuanyuan Shi1,2, Yihong Li1,2, Hongmin Sun1,2, Lifei Wang1,2, Yuhuan Li1, Bingya Jiang1,2, Linzhuan Wu1,2, Bin Hong1,2.
Abstract
A hybrid trans-AT PKS/NRPS gene cluster htm was identified with defined boundaries for hangtaimycin biosynthesis in Streptomyces spectabilis CPCC200148. Deoxyhangtaimycin, a new derivative of hangtaimycin, was identified from the htm11 gene knockout mutant. In vitro biochemical assays demonstrated that the cytochrome P450 monooxygenase Htm11 was responsible for the stereoselective hydroxylation of deoxyhangtaimycin to hangtaimycin. More importantly, deoxyhangtaimycin showed activity against influenza A virus at the micromolar level, highlighting its potential as an antiviral lead compound.Entities:
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Year: 2022 PMID： 35138108 DOI： 10.1021/acs.orglett.2c00242
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005