Literature DB >> 3513298

Quantitation of blood lymphocytes secreting antibodies to pneumococcal polysaccharides after in vivo antigenic stimulation.

C Heilmann, F K Pedersen.   

Abstract

An indirect plaque-forming cell assay detecting B cells secreting IgM, IgG and IgA antibodies against pneumococcal polysaccharides (PPS) is described. The numbers of anti-PPS-secreting cells (SC) and Ig-SC in the blood of normal persons immunized with a polyvalent PPS vaccine were quantitated. Anti-PPS-SC were recorded from the fourth to the twelfth post-vaccination day, and the maximum number was found between days 6 and 9. Quantitatively IgA anti-PPS-SC outnumbered the IgM and IgG anti-PPS-SC. Concomitant with the increase in the numbers of antibody-SC an increase in polyclonally activated IgM-, IgG- and IgA-SC was recorded. The specific anti-PPS-antibody-SC constituted 20-80% of the total numbers of Ig-SC from the sixth to the ninth post-vaccination day.

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Year:  1986        PMID： 3513298     DOI： 10.1111/j.1365-3083.1986.tb01957.x

Source DB:  PubMed          Journal:  Scand J Immunol        ISSN： 0300-9475            Impact factor:   3.487


  9 in total

1.  Phenotypic analysis of pneumococcal polysaccharide-specific B cells.

Authors:  Noor Khaskhely; Jason Mosakowski; Rebecca S Thompson; Sadik Khuder; S Louise Smithson; M A Julie Westerink
Journal:  J Immunol       Date:  2012-01-23       Impact factor: 5.422

2.  Influence of prevaccination immunity on the human B-lymphocyte response to a Haemophilus influenzae type b conjugate vaccine.

Authors:  T Barington; K Kristensen; J Henrichsen; C Heilmann
Journal:  Infect Immun       Date:  1991-03       Impact factor: 3.441

Review 3.  Immunogenicity and immunochemistry of Streptococcus pneumoniae capsular polysaccharides.

Authors:  J E van Dam; A Fleer; H Snippe
Journal:  Antonie Van Leeuwenhoek       Date:  1990-06       Impact factor: 2.271

4.  Number of specific antibody-secreting cells in the peripheral blood among children with mycoplasma pneumonia.

Authors:  M Iseki; T Takahashi; K Kimura; R Yamashita; T Sasaki
Journal:  Infect Immun       Date:  1996-07       Impact factor: 3.441

5.  The immune response to pneumococcal polysaccharides 14 and 23F among elderly individuals consists predominantly of switched memory B cells.

Authors:  David J Leggat; Rebecca S Thompson; Noor M Khaskhely; Anita S Iyer; M A Julie Westerink
Journal:  J Infect Dis       Date:  2013-04-01       Impact factor: 5.226

6.  Interleukin 2 receptor expression by human blood lymphocytes after vaccination with pneumococcal polysaccharides.

Authors:  N Tvede; C Heilmann; L D Christensen
Journal:  Clin Exp Immunol       Date:  1989-06       Impact factor: 4.330

7.  A novel strategy for generating monoclonal antibodies from single, isolated lymphocytes producing antibodies of defined specificities.

Authors:  J S Babcook; K B Leslie; O A Olsen; R A Salmon; J W Schrader
Journal:  Proc Natl Acad Sci U S A       Date:  1996-07-23       Impact factor: 11.205

8.  Modulation of polymorphonuclear cell interleukin-8 secretion by human monoclonal antibodies to type 8 pneumococcal capsular polysaccharide.

Authors:  Tamika Burns; Zhaojing Zhong; Michael Steinitz; Liise-anne Pirofski
Journal:  Infect Immun       Date:  2003-12       Impact factor: 3.441

9.  Antibody-secreting peripheral blood lymphocytes induced by immunization with a conjugate consisting of Streptococcus pneumoniae type 12F polysaccharide and diphtheria toxoid.

Authors:  C Lue; S J Prince; A Fattom; R Schneerson; J B Robbins; J Mestecky
Journal:  Infect Immun       Date:  1990-08       Impact factor: 3.441
  9 in total

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