Sanaa Nassereddine1,2, Rachida Habbal1,3, Yaya Kassogue1,4, Ait Boujmia Oum Kaltoum1, Korchi Farah3, Haraka Majda3, Abou Elfath Rhizlane1, Sellama Nadifi1,5, Hind Dehbi1,5. 1. Laboratory of Cellular and Molecular Pathology, Faculty of Medicine and Pharmacy of Casablanca, Doctoral Training Center, Hassan II University, Casablanca, Morocco. 2. Laboratory of Cytogenetics, Pasteur Institute, Casablanca, Morocco. 3. Department of Cardiology, University Hospital Ibn Rochd, Casablanca, Morocco. 4. Faculty of Medicine and OdontoStomatology, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali. 5. Medical Genetics Unit, University Hospital Ibn Rochd, Casablanca, Morocco.
Abstract
BACKGROUND: Essential hypertension (EH) results from a complex interaction between environmental factors and an individual's genetic background. AIM: To assess the relationship between polymorphisms in GSTM1 and GSTT1 and the risk of EH. SUBJECTS AND METHODS: A multiplex-PCR was used to identify the genotypic profiles of GSTM1 and GSTT1 in 160 patients and 210 controls. RESULTS: The frequency of GSTM1-null genotype was higher in patients younger than 61 years when compared to those over 61 years. Interestingly, GSTT1-null was significantly associated with the risk of EH (OR 4; 95% CI 2.6-6.3; p < 0.0001). While GSTM1-null showed no trend (OR 0.7; 95% CI 0.5-1.1, p = 0.12). Individuals carrying the combined GSTT1-null/GSTM1-null were 2.4 times more at risk for hypertension compared to those harbouring the combined GSTT1-present/GSTM1-present genotype (OR 2.4; 95% CI 1.3-4.4; p = 0.005). Additionally, the presence of the combined GSTT1-null/GSTM1-present was associated with an increased risk of EH compared to GSTT1-present/GSTM1-present carriers (OR 6.75; 95% CI 3.4-13.2; p < 0.0001). CONCLUSION: This study showed that the GSTT1-null alone or in interaction with GSTM1-present or GSTM1-null was associated with a higher risk of hypertension. Moreover, the GSTM1-null seems to be associated with the age of onset of hypertension.
BACKGROUND: Essential hypertension (EH) results from a complex interaction between environmental factors and an individual's genetic background. AIM: To assess the relationship between polymorphisms in GSTM1 and GSTT1 and the risk of EH. SUBJECTS AND METHODS: A multiplex-PCR was used to identify the genotypic profiles of GSTM1 and GSTT1 in 160 patients and 210 controls. RESULTS: The frequency of GSTM1-null genotype was higher in patients younger than 61 years when compared to those over 61 years. Interestingly, GSTT1-null was significantly associated with the risk of EH (OR 4; 95% CI 2.6-6.3; p < 0.0001). While GSTM1-null showed no trend (OR 0.7; 95% CI 0.5-1.1, p = 0.12). Individuals carrying the combined GSTT1-null/GSTM1-null were 2.4 times more at risk for hypertension compared to those harbouring the combined GSTT1-present/GSTM1-present genotype (OR 2.4; 95% CI 1.3-4.4; p = 0.005). Additionally, the presence of the combined GSTT1-null/GSTM1-present was associated with an increased risk of EH compared to GSTT1-present/GSTM1-present carriers (OR 6.75; 95% CI 3.4-13.2; p < 0.0001). CONCLUSION: This study showed that the GSTT1-null alone or in interaction with GSTM1-present or GSTM1-null was associated with a higher risk of hypertension. Moreover, the GSTM1-null seems to be associated with the age of onset of hypertension.
Authors: Juan Zhang; Yan Li; Juan Zou; Chun-Tian Lai; Tian Zeng; Juan Peng; Wen-da Zou; Bei Cao; Dan Liu; Li-Yu Zhu; Hui Li; Yu-Kun Li Journal: Front Oncol Date: 2022-07-28 Impact factor: 5.738