F-18 Fluorodeoxyglucose Positron-Emission Tomography/Computed Tomography Showing Mammillary Body Involvement in a Case of Autoimmune Anti-N-Methyl D-Aspartate Antibody Encephalitis.

Autoimmune encephalitis with antibodies against neuronal cell surface antigens is a group of neuropsychiatric disorders, with anti-N-methyl D-aspartate (NMDAR) encephalitis being one of them. We report a case of a young male patient who presented with complaints of seizures associated with fever, rapidly progressing memory loss, and choreoathetoid movements for 1 month. His serum was strongly positive for anti-NMDAR receptor antibodies. F-18 fluorodeoxyglucose positron-emission tomography/computed tomography for the brain revealed hypermetabolism involving bilateral basal ganglia and bilateral mammillary bodies associated with hypometabolism in bilateral occipital lobes. Copyright:

A 23-year-old male patient came with chief complaints of seizures (2–3 episodes/day) for 1 month associated with altered behavior and fever for 15 days. Later, his ability to respond to verbal commands slowly deteriorated along with the appearance of choreoathetoid movements for 7 days. EEG done for seizure evaluation revealed diffuse encephalitis. Serum tested strongly positive for anti-N-methyl D-aspartate (NMDAR) receptor antibodies (cell-based assays). Axial F-18 fluorodeoxyglucose (FDG) positron-emission tomography (PET), computed tomography (CT), and fused PET/CT brain images [Figure 1a-c] revealed hypermetabolism involving the bilateral basal ganglia (solid arrow) along with hypometabolism in the bilateral occipital cortices (filled arrow) with no morphological abnormality in the corresponding CT images. Axial [Figure 1d-f] and coronal [Figure 1g-i] F-18 FDG PET, CT, and fused PET/CT brain images revealed hypermetabolism involving bilateral mammillary bodies (dotted arrows) relative to cerebral cortex with no morphological abnormality in the corresponding CT images.

Figure 1

Axial F-18 FDG PET, CT, and fused PET/CT brain images (a-c) revealed hypermetabolism involving the bilateral basal ganglia (solid arrow) along with hypometabolism in the bilateral occipital cortices (filled arrow) with no morphological abnormality in the corresponding CT images. Axial (d-f) and coronal (g-i) F-18 FDG PET, CT, and fused PET/CT brain images revealed hypermetabolism in red nucleus. FDG: Fluorodeoxyglucose, PET: Positron-emission tomography, CT: Computed tomography

Anti-NMDAR receptor encephalitis is a most frequently reported autoimmune limbic encephalitis characterized predominantly by IgG antibodies against the GluN1 subunit of MMDA receptor in the cerebrospinal fluid (CSF) and serum.[1] This disorder most frequently affects younger women and children, accounting for 80% of patients, but can also be seen in younger men and older individuals.[2] Most of the patients with this disorder show hypermetabolism involving the hippocampus, amygdala, and parahippocampal gyrus in isolation or bilateral occipital lobe hypometabolism on F-18 FDG PET.[3] In the case of severe neurological disability with choreoathetoid movements, bilateral basal ganglia are involved by these antibodies, as seen in our case.[4] This index case shows rare bilateral mammillary body involvement, representing a pair of paramedian small round bodies located in the undersurface of the brain. These play an important role in recollective memory formation by relaying impulses from the hippocampal region to the anterior thalamus (Papez circuit). Memory loss seen in this case may be attributed to the involvement of bilateral mammillary bodies.

In most cases, the exact trigger mechanism for these antibodies remains unknown, but few studies reported association with herpes viral infections, ovarian and testicular teratomas.[56] Diagnosis is often confirmed by the presence of rapidly progressing clinical symptoms and elevated anti-NMDAR antibodies in the CSF and serum. F-18 FDG PET can support the diagnosis by showing hypermetabolism in the involved structures during the acute phase and also helps to rule out rare yet possible underlying malignancy in the body. Establishing the diagnosis with clinical features, serum investigations, and F-18 FDG PET is important because symptoms associated with this syndrome improve with immunotherapy in more than 60% of the cases.[7] Autoimmune encephalitis with antibodies against neuronal surface antigens confers better prognosis with lesser risk of cancer than those with antibodies against neurocytoplasmic antigen.[89] The findings, in this case, emphasize the potential role of F-18 FDG PET as an imaging biomarker for confirmation of autoimmune encephalitis.

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The authors certify that they have obtained all appropriate patient consent forms. In the form the patient (s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

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Conflicts of interest

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