Roberto Martin Del Campo-Vera1, Austin M Tang2, Angad S Gogia1, Kuang-Hsuan Chen1, Rinu Sebastian1, Zachary D Gilbert1, George Nune3, Charles Y Liu4, Spencer Kellis5, Brian Lee4. 1. Department of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA. 2. Department of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA. Electronic address: austint@usc.edu. 3. Department of Neurology, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA; USC Neurorestoration Center, Keck School of Medicine of USC, Los Angeles, CA, USA. 4. Department of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA; USC Neurorestoration Center, Keck School of Medicine of USC, Los Angeles, CA, USA; Department of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. 5. Department of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA; USC Neurorestoration Center, Keck School of Medicine of USC, Los Angeles, CA, USA; Department of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA; Tianqiao and Chrissy Chen Brain-Machine Interface Center, Chen Institute for Neuroscience, California Institute of Technology, Pasadena, CA, USA.
Abstract
INTRODUCTION: The hippocampus is thought to be involved in movement, but its precise role in movement execution and inhibition has not been well studied. Previous work with direct neural recordings has found beta-band (13-30 Hz) modulation in both movement execution and inhibition throughout the motor system, but the role of beta-band modulation in the hippocampus during movement inhibition is not well understood. Here, we perform a Go/No-Go reaching task in ten patients with medically refractory epilepsy to study human hippocampal beta-power changes during movement. MATERIALS AND METHODS: Ten epilepsy patients (5 female; ages 21-46) were implanted with intracranial depth electrodes for seizure monitoring and localization. Local field potentials were sampled at 2000 Hz during a Go/No-Go movement task. Comparison of beta-band power between Go and No-Go conditions was conducted using Wilcoxon signed-rank hypothesis testing for each patient. Sub-analyses were conducted to assess differences in the anterior vs posterior contacts, ipsilateral vs contralateral contacts, and male vs female beta-power values. RESULTS: Eight out of ten patients showed significant beta-power decreases during the Go movement response (p < 0.05) compared to baseline. Eight out of ten patients also showed significant beta-power increases in the No-Go condition, occurring in the absence of movement. No significant differences were noted between ipsilateral vs contralateral contacts nor in anterior vs posterior hippocampal contacts. Female participants had a higher task success rate than males and had significantly greater beta-power increases in the No-Go condition (p < 0.001). CONCLUSION: These findings indicate that increases in hippocampal beta power are associated with movement inhibition. To the best of our knowledge, this study is the first to report this phenomenon in the human hippocampus. The beta band may represent a state-change signal involved in motor processing. Future focus on the beta band in understanding human motor and impulse control will be vital.
INTRODUCTION: The hippocampus is thought to be involved in movement, but its precise role in movement execution and inhibition has not been well studied. Previous work with direct neural recordings has found beta-band (13-30 Hz) modulation in both movement execution and inhibition throughout the motor system, but the role of beta-band modulation in the hippocampus during movement inhibition is not well understood. Here, we perform a Go/No-Go reaching task in ten patients with medically refractory epilepsy to study human hippocampal beta-power changes during movement. MATERIALS AND METHODS: Ten epilepsy patients (5 female; ages 21-46) were implanted with intracranial depth electrodes for seizure monitoring and localization. Local field potentials were sampled at 2000 Hz during a Go/No-Go movement task. Comparison of beta-band power between Go and No-Go conditions was conducted using Wilcoxon signed-rank hypothesis testing for each patient. Sub-analyses were conducted to assess differences in the anterior vs posterior contacts, ipsilateral vs contralateral contacts, and male vs female beta-power values. RESULTS: Eight out of ten patients showed significant beta-power decreases during the Go movement response (p < 0.05) compared to baseline. Eight out of ten patients also showed significant beta-power increases in the No-Go condition, occurring in the absence of movement. No significant differences were noted between ipsilateral vs contralateral contacts nor in anterior vs posterior hippocampal contacts. Female participants had a higher task success rate than males and had significantly greater beta-power increases in the No-Go condition (p < 0.001). CONCLUSION: These findings indicate that increases in hippocampal beta power are associated with movement inhibition. To the best of our knowledge, this study is the first to report this phenomenon in the human hippocampus. The beta band may represent a state-change signal involved in motor processing. Future focus on the beta band in understanding human motor and impulse control will be vital.
Authors: Per B Sederberg; Andreas Schulze-Bonhage; Joseph R Madsen; Edward B Bromfield; David C McCarthy; Armin Brandt; Michele S Tully; Michael J Kahana Journal: Cereb Cortex Date: 2006-07-10 Impact factor: 5.357
Authors: Zachary D Gilbert; Roberto Martin Del Campo-Vera; Austin M Tang; Kuang-Hsuan Chen; Rinu Sebastian; Arthur Shao; Emiliano Tabarsi; Ryan S Chung; Andrea Leonor; Shivani Sundaram; Christi Heck; George Nune; Charles Y Liu; Spencer Kellis; Brian Lee Journal: J Neural Eng Date: 2022-07-22 Impact factor: 5.043