Literature DB >> 35123238

Activation of endo-lysosomal two-pore channels by NAADP and PI(3,5)P2. Five things to know.

Sandip Patel1, Yu Yuan2, Gihan S Gunaratne3, Taufiq Rahman4, Jonathan S Marchant3.   

Abstract

Two-pore channels are ancient members of the voltage-gated ion channel superfamily that are expressed predominantly on acidic organelles such as endosomes and lysosomes. Here we review recent advances in understanding how TPCs are activated by their ligands and identify five salient features: (1) TPCs are Ca2+-permeable non-selective cation channels gated by NAADP. (2) NAADP activation is indirect through associated NAADP receptors. (3) TPCs are also Na+-selective channels gated by PI(3,5)P2. (4) PI(3,5)P2 activation is direct through a structurally-resolved binding site. (5) TPCs switch their ion selectivity in an agonist-dependent manner.
Copyright © 2022. Published by Elsevier Ltd.

Entities:  

Keywords:  Ca2+; Endosomes; JPT2; LSM12; Lysosomes; TPC1; TPC2:TPC3; TPCN1; TPCN2; TPCN3

Mesh：

Substances：

Year:  2022        PMID： 35123238      PMCID： PMC9552313          DOI： 10.1016/j.ceca.2022.102543

Source DB:  PubMed          Journal:  Cell Calcium        ISSN： 0143-4160            Impact factor:   4.690


  75 in total

1.  The mechanism and energetics of a ligand-controlled hydrophobic gate in a mammalian two pore channel.

Authors:  Stefan Milenkovic; Igor V Bodrenko; Laura Lagostena; Antonella Gradogna; Giovanni Serra; Andrea Bosin; Armando Carpaneto; Matteo Ceccarelli
Journal:  Phys Chem Chem Phys       Date:  2020-07-03       Impact factor: 3.676

2.  Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance.

Authors:  Spencer A Freeman; Stefan Uderhardt; Amra Saric; Richard F Collins; Catherine M Buckley; Sivakami Mylvaganam; Parastoo Boroumand; Jonathan Plumb; Ronald N Germain; Dejian Ren; Sergio Grinstein
Journal:  Science       Date:  2019-12-05       Impact factor: 47.728

3.  Nicotinic Acid Adenine Dinucleotide 2'-Phosphate (NAADP) Binding Proteins in T-Lymphocytes.

Authors:  Timothy F Walseth; Yaping Lin-Moshier; Karin Weber; Jonathan S Marchant; James T Slama; Andreas H Guse
Journal:  Messenger (Los Angel)       Date:  2012-06-01

4.  mTORC1 controls lysosomal Ca2+ release through the two-pore channel TPC2.

Authors:  Oluseye A Ogunbayo; Jingxian Duan; Jian Xiong; Qiaochu Wang; Xinghua Feng; Jianjie Ma; Michael X Zhu; A Mark Evans
Journal:  Sci Signal       Date:  2018-04-10       Impact factor: 8.192

5.  Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells.

Authors:  Margarida Ruas; Lianne C Davis; Cheng-Chang Chen; Anthony J Morgan; Kai-Ting Chuang; Timothy F Walseth; Christian Grimm; Clive Garnham; Trevor Powell; Nick Platt; Frances M Platt; Martin Biel; Christian Wahl-Schott; John Parrington; Antony Galione
Journal:  EMBO J       Date:  2015-04-14       Impact factor: 11.598

6.  Two-pore Channels Enter the Atomic Era: Structure of Plant TPC Revealed.

Authors:  Sandip Patel; Christopher J Penny; Taufiq Rahman
Journal:  Trends Biochem Sci       Date:  2016-05-04       Impact factor: 13.807

7.  The human two-pore channel 1 is modulated by cytosolic and luminal calcium.

Authors:  Laura Lagostena; Margherita Festa; Michael Pusch; Armando Carpaneto
Journal:  Sci Rep       Date:  2017-03-02       Impact factor: 4.379

8.  Structural insights into the voltage and phospholipid activation of the mammalian TPC1 channel.

Authors:  Ji She; Jiangtao Guo; Qingfeng Chen; Weizhong Zeng; Youxing Jiang; Xiao-Chen Bai
Journal:  Nature       Date:  2018-03-21       Impact factor: 49.962

9.  Mining of Ebola virus entry inhibitors identifies approved drugs as two-pore channel pore blockers.

Authors:  Christopher J Penny; Kristin Vassileva; Archana Jha; Yu Yuan; Xavier Chee; Elizabeth Yates; Michela Mazzon; Bethan S Kilpatrick; Shmuel Muallem; Mark Marsh; Taufiq Rahman; Sandip Patel
Journal:  Biochim Biophys Acta Mol Cell Res       Date:  2018-11-05       Impact factor: 4.739

10.  Lsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles.

Authors:  Jiyuan Zhang; Xin Guan; Kunal Shah; Jiusheng Yan
Journal:  Nat Commun       Date:  2021-08-06       Impact factor: 14.919
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  2 in total

1.  TMBIM5 loss of function alters mitochondrial matrix ion homeostasis and causes a skeletal myopathy.

Authors:  Li Zhang; Felicia Dietsche; Bruno Seitaj; Liliana Rojas-Charry; Nadina Latchman; Dhanendra Tomar; Rob Ci Wüst; Alexander Nickel; Katrin Bm Frauenknecht; Benedikt Schoser; Sven Schumann; Michael J Schmeisser; Johannes Vom Berg; Thorsten Buch; Stefanie Finger; Philip Wenzel; Christoph Maack; John W Elrod; Jan B Parys; Geert Bultynck; Axel Methner
Journal:  Life Sci Alliance       Date:  2022-06-17

Review 2.  Dysregulated Ca2+ Homeostasis as a Central Theme in Neurodegeneration: Lessons from Alzheimer's Disease and Wolfram Syndrome.

Authors:  Manon Callens; Jens Loncke; Geert Bultynck
Journal:  Cells       Date:  2022-06-18       Impact factor: 7.666
  2 in total

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