Literature DB >> 3512294

Chemical characterization and opioid activity of an exorphin isolated from in vivo digests of casein.

H Meisel.   

Abstract

The in vivo formation of an opioid peptide (exorphin) derived from beta-casein has been proved for the first time. It was isolated from duodenal chyme of minipigs after feeding with the milk protein casein. The exorphin has been identified as a beta-casein fragment by end-group determinations and qualitative amino acid analysis of the purified peptide. This peptide, named beta-casomorphin-11, displayed substantial opioid activity in an opiate receptor-binding assay.

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Year:  1986        PMID： 3512294     DOI： 10.1016/0014-5793(86)80251-4

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  7 in total

1.  Identification of a novel opioid peptide (Tyr-Val-Pro-Phe-Pro) derived from human alpha S1 casein (alpha S1-casomorphin, and alpha S1-casomorphin amide).

Authors:  M Kampa; S Loukas; A Hatzoglou; P Martin; P M Martin; E Castanas
Journal:  Biochem J       Date:  1996-11-01       Impact factor: 3.857

Review 2.  Biologically active peptides in milk proteins.

Authors:  H Meisel; H Frister; E Schlimme
Journal:  Z Ernahrungswiss       Date:  1989-12

3.  Effect of casein-derived peptides on D-xylose absorption assessed by H2 breath test in normal volunteers.

Authors:  C Defilippi; A M Madrid; K Salas; L Michea; N Lagos
Journal:  Dig Dis Sci       Date:  2000-04       Impact factor: 3.199

4.  Insight into subtilisin E-S7 cleavage pattern based on crystal structure and hydrolysates peptide analysis.

Authors:  Heng Tang; Juan Zhang; Ke Shi; Hideki Aihara; Guocheng Du
Journal:  Biochem Biophys Res Commun       Date:  2019-03-23       Impact factor: 3.575

5.  Effects of intra-gastric beta-casomorphin-7 on somatostatin and gastrin gene expression in rat gastric mucosa.

Authors:  Ya-Feng Zong; Wei-Hua Chen; Yuan-Shu Zhang; Si-Xiang Zou
Journal:  World J Gastroenterol       Date:  2007-04-14       Impact factor: 5.742

6.  Production of Cow's Milk Free from Beta-Casein A1 and Its Application in the Manufacturing of Specialized Foods for Early Infant Nutrition.

Authors:  Miguel Á Duarte-Vázquez; Carlos García-Ugalde; Laura M Villegas-Gutiérrez; Blanca E García-Almendárez; Jorge L Rosado
Journal:  Foods       Date:  2017-07-12

Review 7.  Systematic Review of the Gastrointestinal Effects of A1 Compared with A2 β-Casein.

Authors:  Simon Brooke-Taylor; Karen Dwyer; Keith Woodford; Natalya Kost
Journal:  Adv Nutr       Date:  2017-09-15       Impact factor: 8.701
  7 in total

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