Catherine C Cohen1,2, Ellen C Francis2, Wei Perng2,3,4, Katherine A Sauder1,2, Ann Scherzinger5, Shikha S Sundaram1, Kartik Shankar1,2, Dana Dabelea1,2,3. 1. Department of Pediatrics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. 2. Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. 3. Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. 4. Department of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA. 5. Department of Radiology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Abstract
BACKGROUND: Intrauterine overnutrition has been associated with paediatric nonalcoholic fatty liver disease (NAFLD), but the exact mechanisms involved remain unclear. OBJECTIVE: To examine whether maternal fuels and metabolic markers during pregnancy are associated with offspring hepatic fat in childhood. METHODS: This analysis included 286 mother-child pairs from the Healthy Start Study, a longitudinal pre-birth cohort in Colorado. Fasting blood draws were collected in early pregnancy (~17 weeks) and mid-pregnancy (~27 weeks). Offspring hepatic fat was assessed by magnetic resonance imaging (MRI) at ~5 years. RESULTS: In early pregnancy, maternal triglycerides (TGs) and free fatty acids (FFAs) were positively associated with offspring hepatic fat [Back-transformed β (95% CI): 1.15 (1.05, 1.27) per 1 standard deviation (SD) TGs; 1.14 (1.05, 1.23) per 1 SD FFAs]. Maternal total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) were also associated with offspring hepatic fat, but only among boys [1.22 (1.08, 1.37) per 1 SD TC; 1.21 (1.07, 1.37) per 1 SD LDL-C]. In mid-pregnancy, only maternal TGs remained associated with offspring hepatic fat. Adjusting for potential confounders or mediators did not affect associations. CONCLUSIONS: Maternal lipid concentrations, especially in early pregnancy, are associated with higher offspring hepatic fat, and may, therefore, be targeted in future interventions among pregnant women.
BACKGROUND: Intrauterine overnutrition has been associated with paediatric nonalcoholic fatty liver disease (NAFLD), but the exact mechanisms involved remain unclear. OBJECTIVE: To examine whether maternal fuels and metabolic markers during pregnancy are associated with offspring hepatic fat in childhood. METHODS: This analysis included 286 mother-child pairs from the Healthy Start Study, a longitudinal pre-birth cohort in Colorado. Fasting blood draws were collected in early pregnancy (~17 weeks) and mid-pregnancy (~27 weeks). Offspring hepatic fat was assessed by magnetic resonance imaging (MRI) at ~5 years. RESULTS: In early pregnancy, maternal triglycerides (TGs) and free fatty acids (FFAs) were positively associated with offspring hepatic fat [Back-transformed β (95% CI): 1.15 (1.05, 1.27) per 1 standard deviation (SD) TGs; 1.14 (1.05, 1.23) per 1 SD FFAs]. Maternal total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) were also associated with offspring hepatic fat, but only among boys [1.22 (1.08, 1.37) per 1 SD TC; 1.21 (1.07, 1.37) per 1 SD LDL-C]. In mid-pregnancy, only maternal TGs remained associated with offspring hepatic fat. Adjusting for potential confounders or mediators did not affect associations. CONCLUSIONS: Maternal lipid concentrations, especially in early pregnancy, are associated with higher offspring hepatic fat, and may, therefore, be targeted in future interventions among pregnant women.
Authors: Teresa A Hillier; Kathryn L Pedula; Mark M Schmidt; Judith A Mullen; Marie-Aline Charles; David J Pettitt Journal: Diabetes Care Date: 2007-05-22 Impact factor: 19.112
Authors: Oyekoya T Ayonrinde; Wendy H Oddy; Leon A Adams; Trevor A Mori; Lawrence J Beilin; Nicholas de Klerk; John K Olynyk Journal: J Hepatol Date: 2017-06-12 Impact factor: 25.083
Authors: Lisa Chasan-Taber; Michael D Schmidt; Dawn E Roberts; David Hosmer; Glenn Markenson; Patty S Freedson Journal: Med Sci Sports Exerc Date: 2004-10 Impact factor: 5.411
Authors: Allison L B Shapiro; Sarah J Schmiege; John T Brinton; Deborah Glueck; Tessa L Crume; Jacob E Friedman; Dana Dabelea Journal: Diabetologia Date: 2015-01-28 Impact factor: 10.122
Authors: Amandeep K Sahota; Warren L Shapiro; Kimberly P Newton; Steven T Kim; Joanie Chung; Jeffrey B Schwimmer Journal: Pediatrics Date: 2020-12 Impact factor: 7.124
Authors: Stephanie R Thorn; Karalee C Baquero; Sean A Newsom; Karim C El Kasmi; Bryan C Bergman; Gerald I Shulman; Kevin L Grove; Jacob E Friedman Journal: Diabetes Date: 2014-04-04 Impact factor: 9.461
Authors: Ashok Mandala; Evgenia Dobrinskikh; Rachel C Janssen; Oliver Fiehn; Angelo D'Alessandro; Jacob E Friedman; Karen R Jonscher Journal: Int J Mol Sci Date: 2022-05-27 Impact factor: 6.208