| Literature DB >> 35121872 |
Lisa Derosa1,2,3, Cléa Melenotte1,2,4,5, Franck Griscelli1,6, Bertrand Gachot1,7, Aurélien Marabelle1,2,3, Guido Kroemer8,9,10,11,12, Laurence Zitvogel13,14,15,16,17.
Abstract
Coronavirus disease 2019 (COVID-19) and its causative virus, SARS-CoV-2, pose considerable challenges for the management of oncology patients. COVID-19 presents as a particularly severe respiratory and systemic infection in aging and immunosuppressed individuals, including patients with cancer. Moreover, severe COVID-19 is linked to an inflammatory burst and lymphopenia, which may aggravate cancer prognosis. Here we discuss why those with cancer are at higher risk of severe COVID-19, describe immune responses that confer protective or adverse reactions to this disease and indicate which antineoplastic therapies may either increase COVID-19 vulnerability or have a dual therapeutic effect on cancer and COVID-19.Entities:
Mesh:
Year: 2020 PMID: 35121872 DOI: 10.1038/s43018-020-00122-3
Source DB: PubMed Journal: Nat Cancer ISSN: 2662-1347