| Literature DB >> 35121107 |
Zi-Jie Long1, Jun-Dan Wang2, Jue-Qiong Xu2, Xin-Xing Lei3, Quentin Liu4.
Abstract
The correct duplication and transfer of genetic material to daughter cells is the major event of cell division. Dysfunction of DNA replication or chromosome segregation presents challenges in cancer initiation and development as well as opportunities for cancer treatment. Cyclic GMP-AMP synthase (cGAS) of the innate immune system detects cytoplasmic DNA and mediates downstream immune responses through the molecule stimulator of interferon genes (STING). However, how cytosolic DNA sensor cGAS participates in guaranteeing accurate cell division and preventing tumorigenesis is still unclear. Recent evidence indicates malfunction of cGAS/STING pathway in cancer progression. Cell cycle-targeted therapy synergizes with immunotherapy via cGAS/STING activation, leading to promising therapeutic benefit. Here, we review the interactions between cell cycle regulation and cGAS/STING signaling, thus enabling us to understand the role of cGAS/STING in cancer initiation, development, and treatment.Entities:
Keywords: cGAS/STING; cell cycle; immunotherapy; tumorigenesis
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Year: 2022 PMID： 35121107 PMCID： PMC8899703 DOI： 10.1016/j.ymthe.2022.01.044
Source DB: PubMed Journal: Mol Ther ISSN： 1525-0016 Impact factor: 11.454