Literature DB >> 35120619

iPSC-based disease modeling and drug discovery in cardinal neurodegenerative disorders.

Hideyuki Okano1, Satoru Morimoto2.   

Abstract

It has been 15 years since the birth of human induced pluripotent stem cell (iPSC) technology in 2007, and the scope of its application has been expanding. In addition to the development of cell therapies using iPSC-derived cells, pathological analyses using disease-specific iPSCs and clinical trials to confirm the safety and efficacy of drugs developed using iPSCs are progressing. With the innovation of related technologies, iPSC applications are about to enter a new stage. This review outlines advances in iPSC modeling and therapeutic development for cardinal neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson's disease, and Alzheimer's disease.
Copyright © 2022 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  AD; ALS; Alzheimer’s disease; PD; Parkinson’s disease; amyotrophic lateral sclerosis; disease modeling; drug repositioning; iPSCs; induced pluripotent stem cells; stratification

Mesh：

Year:  2022        PMID： 35120619     DOI： 10.1016/j.stem.2022.01.007

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  4 in total

Review 1.  Genetics of amyotrophic lateral sclerosis: seeking therapeutic targets in the era of gene therapy.

Authors:  Naoki Suzuki; Ayumi Nishiyama; Hitoshi Warita; Masashi Aoki
Journal:  J Hum Genet       Date:  2022-06-13       Impact factor: 3.172

2.  Suppression of Wnt/β-Catenin Signaling Is Associated with Downregulation of Wnt1, PORCN, and Rspo2 in Alzheimer's Disease.

Authors:  Jesse R Macyczko; Na Wang; Jing Zhao; Yingxue Ren; Wenyan Lu; Tadafumi C Ikezu; Na Zhao; Chia-Chen Liu; Guojun Bu; Yonghe Li
Journal:  Mol Neurobiol       Date:  2022-10-10       Impact factor: 5.682

3.  Pathogenic Mutation of TDP-43 Impairs RNA Processing in a Cell Type-Specific Manner: Implications for the Pathogenesis of ALS/FTLD.

Authors:  Kent Imaizumi; Hirosato Ideno; Tsukika Sato; Satoru Morimoto; Hideyuki Okano
Journal:  eNeuro       Date:  2022-06-08

4.  Single transcription factor efficiently leads human induced pluripotent stem cells to functional microglia.

Authors:  Iki Sonn; Fumiko Honda-Ozaki; Sho Yoshimatsu; Satoru Morimoto; Hirotaka Watanabe; Hideyuki Okano
Journal:  Inflamm Regen       Date:  2022-07-01
  4 in total

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