Importance: New symptoms and conditions can develop following SARS-CoV-2 infection. Whether they occur more frequently among persons with SARS-CoV-2 infection compared with those without is unclear. Objective: To compare the prevalence of new diagnoses of select symptoms and conditions between 31 and 150 days after testing among persons who tested positive vs negative for SARS-CoV-2. Design, Setting, and Participants: This cohort study analyzed aggregated electronic health record data from 40 health care systems, including 338 024 persons younger than 20 years and 1 790 886 persons aged 20 years or older who were tested for SARS-CoV-2 during March to December 2020 and who had medical encounters between 31 and 150 days after testing. Main Outcomes and Measures: International Statistical Classification of Diseases, Tenth Revision, Clinical Modification codes were used to capture new symptoms and conditions that were recorded 31 to 150 days after a SARS-CoV-2 test but absent in the 18 months to 7 days prior to testing. The prevalence of new symptoms and conditions was compared between persons with positive and negative SARS-CoV-2 tests stratified by age (20 years or older and young than 20 years) and care setting (nonhospitalized, hospitalized, or hospitalized and ventilated). Results: A total of 168 701 persons aged 20 years or older and 26 665 younger than 20 years tested positive for SARS-CoV-2, and 1 622 185 persons aged 20 years or older and 311 359 younger than 20 years tested negative. Shortness of breath was more common among persons with a positive vs negative test result among hospitalized patients (≥20 years: prevalence ratio [PR], 1.89 [99% CI, 1.79-2.01]; <20 years: PR, 1.72 [99% CI, 1.17-2.51]). Shortness of breath was also more common among nonhospitalized patients aged 20 years or older with a positive vs negative test result (PR, 1.09 [99% CI, 1.05-1.13]). Among hospitalized persons aged 20 years or older, the prevalence of new fatigue (PR, 1.35 [99% CI, 1.27-1.44]) and type 2 diabetes (PR, 2.03 [99% CI, 1.87-2.19]) was higher among those with a positive vs a negative test result. Among hospitalized persons younger than 20 years, the prevalence of type 2 diabetes (PR, 2.14 [99% CI, 1.13-4.06]) was higher among those with a positive vs a negative test result; however, the prevalence difference was less than 1%. Conclusions and Relevance: In this cohort study, among persons hospitalized after a positive SARS-CoV-2 test result, diagnoses of certain symptoms and conditions were higher than among those with a negative test result. Health care professionals should be aware of symptoms and conditions that may develop after SARS-CoV-2 infection, particularly among those hospitalized after diagnosis.
Importance: New symptoms and conditions can develop following SARS-CoV-2 infection. Whether they occur more frequently among persons with SARS-CoV-2 infection compared with those without is unclear. Objective: To compare the prevalence of new diagnoses of select symptoms and conditions between 31 and 150 days after testing among persons who tested positive vs negative for SARS-CoV-2. Design, Setting, and Participants: This cohort study analyzed aggregated electronic health record data from 40 health care systems, including 338 024 persons younger than 20 years and 1 790 886 persons aged 20 years or older who were tested for SARS-CoV-2 during March to December 2020 and who had medical encounters between 31 and 150 days after testing. Main Outcomes and Measures: International Statistical Classification of Diseases, Tenth Revision, Clinical Modification codes were used to capture new symptoms and conditions that were recorded 31 to 150 days after a SARS-CoV-2 test but absent in the 18 months to 7 days prior to testing. The prevalence of new symptoms and conditions was compared between persons with positive and negative SARS-CoV-2 tests stratified by age (20 years or older and young than 20 years) and care setting (nonhospitalized, hospitalized, or hospitalized and ventilated). Results: A total of 168 701 persons aged 20 years or older and 26 665 younger than 20 years tested positive for SARS-CoV-2, and 1 622 185 persons aged 20 years or older and 311 359 younger than 20 years tested negative. Shortness of breath was more common among persons with a positive vs negative test result among hospitalized patients (≥20 years: prevalence ratio [PR], 1.89 [99% CI, 1.79-2.01]; <20 years: PR, 1.72 [99% CI, 1.17-2.51]). Shortness of breath was also more common among nonhospitalized patients aged 20 years or older with a positive vs negative test result (PR, 1.09 [99% CI, 1.05-1.13]). Among hospitalized persons aged 20 years or older, the prevalence of new fatigue (PR, 1.35 [99% CI, 1.27-1.44]) and type 2 diabetes (PR, 2.03 [99% CI, 1.87-2.19]) was higher among those with a positive vs a negative test result. Among hospitalized persons younger than 20 years, the prevalence of type 2 diabetes (PR, 2.14 [99% CI, 1.13-4.06]) was higher among those with a positive vs a negative test result; however, the prevalence difference was less than 1%. Conclusions and Relevance: In this cohort study, among persons hospitalized after a positive SARS-CoV-2 test result, diagnoses of certain symptoms and conditions were higher than among those with a negative test result. Health care professionals should be aware of symptoms and conditions that may develop after SARS-CoV-2 infection, particularly among those hospitalized after diagnosis.
Authors: Annachiara Marra; Pratik P Pandharipande; Timothy D Girard; Mayur B Patel; Christopher G Hughes; James C Jackson; Jennifer L Thompson; Rameela Chandrasekhar; Eugene Wesley Ely; Nathan E Brummel Journal: Crit Care Med Date: 2018-09 Impact factor: 7.598
Authors: Sarah E Daugherty; Yinglong Guo; Kevin Heath; Micah C Dasmariñas; Karol Giuseppe Jubilo; Jirapat Samranvedhya; Marc Lipsitch; Ken Cohen Journal: BMJ Date: 2021-05-19
Authors: Christopher B Forrest; Kathleen M McTigue; Adrian F Hernandez; Lauren W Cohen; Henry Cruz; Kevin Haynes; Rainu Kaushal; Abel N Kho; Keith A Marsolo; Vinit P Nair; Richard Platt; Jon E Puro; Russell L Rothman; Elizabeth A Shenkman; Lemuel Russell Waitman; Neely A Williams; Thomas W Carton Journal: J Clin Epidemiol Date: 2020-09-28 Impact factor: 6.437
Authors: Ismail M Osmanov; Ekaterina Spiridonova; Polina Bobkova; Aysylu Gamirova; Anastasia Shikhaleva; Margarita Andreeva; Oleg Blyuss; Yasmin El-Taravi; Audrey DunnGalvin; Pasquale Comberiati; Diego G Peroni; Christian Apfelbacher; Jon Genuneit; Lyudmila Mazankova; Alexandra Miroshina; Evgeniya Chistyakova; Elmira Samitova; Svetlana Borzakova; Elena Bondarenko; Anatoliy A Korsunskiy; Irina Konova; Sarah Wulf Hanson; Gail Carson; Louise Sigfrid; Janet T Scott; Matthew Greenhawt; Elizabeth A Whittaker; Elena Garralda; Olivia V Swann; Danilo Buonsenso; Dasha E Nicholls; Frances Simpson; Christina Jones; Malcolm G Semple; John O Warner; Theo Vos; Piero Olliaro; Daniel Munblit Journal: Eur Respir J Date: 2022-02-03 Impact factor: 16.671
Authors: Lyudmyla Kompaniyets; Lara Bull-Otterson; Tegan K Boehmer; Sarah Baca; Pablo Alvarez; Kai Hong; Joy Hsu; Aaron M Harris; Adi V Gundlapalli; Sharon Saydah Journal: MMWR Morb Mortal Wkly Rep Date: 2022-08-05 Impact factor: 35.301
Authors: Sara Y Tartof; Deborah E Malden; In-Lu Amy Liu; Lina S Sy; Bruno J Lewin; Joshua T B Williams; Simon J Hambidge; Jonathan D Alpern; Matthew F Daley; Jennifer C Nelson; David McClure; Ousseny Zerbo; Michelle L Henninger; Candace Fuller; Eric Weintraub; Sharon Saydah; Lei Qian Journal: JAMA Netw Open Date: 2022-08-01