Current perspectives on naturally occurring saponins as anticancer agents.

Saponins, a heterogeneous group of sterol and triterpene glycosides, are distributed widely in nature. Naturally occurring saponins could act on diverse targets in cancer cells and consequently exert potential antiproliferative effects in various cancers, including drug-resistant forms. Therefore, naturally occurring saponins are useful templates for the discovery of novel anticancer candidates. Covering articles published between January 2020 and October 2021, this review aims to outline the recent development of naturally occurring steroidal and triterpenoidal saponins with anticancer potential to provide novel anticancer lead hits/candidates.