Literature DB >> 3511903

Human renin: a new class of inhibitors.

J G Dann, D K Stammers, C J Harris, R J Arrowsmith, D E Davies, G W Hardy, J A Morton.   

Abstract

A new class of human renin inhibitor is described, containing a novel analogue of the peptide bond. High inhibitory potency was observed for octapeptide-length substrate analogues but inhibition progressively weakened as the molecule was shortened from the amino terminal end.

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Year:  1986        PMID: 3511903     DOI: 10.1016/0006-291x(86)90528-0

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN: 0006-291X            Impact factor:   3.575


  6 in total

1.  X-ray crystallographic structure of a complex between a synthetic protease of human immunodeficiency virus 1 and a substrate-based hydroxyethylamine inhibitor.

Authors:  A L Swain; M M Miller; J Green; D H Rich; J Schneider; S B Kent; A Wlodawer
Journal:  Proc Natl Acad Sci U S A       Date:  1990-11       Impact factor: 11.205

2.  Stability and activity of human immunodeficiency virus protease: comparison of the natural dimer with a homologous, single-chain tethered dimer.

Authors:  Y S Cheng; F H Yin; S Foundling; D Blomstrom; C A Kettner
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

3.  Development of a sensitive activity assay for high-volume evaluation of human renin inhibitory peptides in rat serum: results with U-71,038.

Authors:  M J Ruwart; S K Sharma; D W Harris; D B Lakings; B D Rush; K F Wilkinson; J C Cornette; D B Evans; J M Friis; K J Cook
Journal:  Pharm Res       Date:  1990-04       Impact factor: 4.200

Review 4.  Renin inhibitors.

Authors:  W J Greenlee
Journal:  Pharm Res       Date:  1987-10       Impact factor: 4.200

5.  Renin inhibitor: relationship between molecular structure and oral absorption.

Authors:  N Hashimoto; T Fujioka; K Hayashi; K Odaguchi; T Toyoda; M Nakamura; K Hirano
Journal:  Pharm Res       Date:  1994-10       Impact factor: 4.200

6.  Drug discovery prospect from untapped species: indications from approved natural product drugs.

Authors:  Feng Zhu; Xiao Hua Ma; Chu Qin; Lin Tao; Xin Liu; Zhe Shi; Cun Long Zhang; Chun Yan Tan; Yu Zong Chen; Yu Yang Jiang
Journal:  PLoS One       Date:  2012-07-11       Impact factor: 3.240

  6 in total

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