Literature DB >> 35118618

DNA Vaccines in Pigs: From Immunization to Antigen Identification.

Francesc Accensi1,2, Laia Bosch-Camós3, Paula L Monteagudo3, Fernando Rodríguez3.   

Abstract

DNA vaccination is one of the most fascinating vaccine strategies currently in development. Two of the main advantages of DNA immunization rely on its simplicity and flexibility, being ideal to dissect both the immune mechanisms and the antigens involved in protection against a given pathogen. Here we describe several strategies used to enhance the immune responses induced and the protection afforded by experimental DNA vaccines tested in swine and provide very basic protocols describing the generation and in vivo application of a prototypic DNA vaccine. The future will say the last word regarding the definitive implementation of DNA vaccination in the field.
© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  APC; Antibodies; Antigen presentation; Cytotoxic T-cells (CTL); DNA vaccine; ELI; Electroporation; Genetic adjuvant; Swine; Veterinary virology

Mesh：

Substances：

Year:  2022        PMID： 35118618     DOI： 10.1007/978-1-0716-2168-4_6

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  39 in total

Review 1.  A role for liposomes in genetic vaccination.

Authors:  Gregory Gregoriadis; Andrew Bacon; Wilson Caparros-Wanderley; Brenda McCormack
Journal:  Vaccine       Date:  2002-12-20       Impact factor: 3.641

2.  Genetic immunization is a simple method for eliciting an immune response.

Authors:  D C Tang; M DeVit; S A Johnston
Journal:  Nature       Date:  1992-03-12       Impact factor: 49.962

Review 3.  DNA vaccines against viral diseases of farmed fish.

Authors:  Øystein Evensen; Jo-Ann C Leong
Journal:  Fish Shellfish Immunol       Date:  2013-10-31       Impact factor: 4.581

4.  Oral vaccination with a liposome-encapsulated influenza DNA vaccine protects mice against respiratory challenge infection.

Authors:  Jing Liu; Jianqi Wu; Bing Wang; Sheng Zeng; Feifei Qi; Changlong Lu; Yoshinobu Kimura; Beixing Liu
Journal:  J Med Virol       Date:  2013-09-30       Impact factor: 2.327

5.  Contribution of cells at the site of DNA vaccination to the generation of antigen-specific immunity and memory.

Authors:  D M Klinman; J M Sechler; J Conover; M Gu; A S Rosenberg
Journal:  J Immunol       Date:  1998-03-01       Impact factor: 5.422

Review 6.  Particle-mediated nucleic acid immunization.

Authors:  J R Haynes; D E McCabe; W F Swain; G Widera; J T Fuller
Journal:  J Biotechnol       Date:  1996-01-26       Impact factor: 3.307

7.  Contribution of CpG motifs to the immunogenicity of DNA vaccines.

Authors:  D M Klinman; G Yamshchikov; Y Ishigatsubo
Journal:  J Immunol       Date:  1997-04-15       Impact factor: 5.422

8.  Enhancing DNA immunization by targeting ASFV antigens to SLA-II bearing cells.

Authors:  J M Argilaguet; E Pérez-Martín; C Gallardo; F J Salguero; B Borrego; A Lacasta; F Accensi; I Díaz; M Nofrarías; J Pujols; E Blanco; M Pérez-Filgueira; J M Escribano; F Rodríguez
Journal:  Vaccine       Date:  2011-06-14       Impact factor: 3.641

Review 9.  Preclinical and clinical progress of particle-mediated DNA vaccines for infectious diseases.

Authors:  Deborah H Fuller; Peter Loudon; Connie Schmaljohn
Journal:  Methods       Date:  2006-09       Impact factor: 3.608

10.  A DNA vaccine expressing the E2 protein of classical swine fever virus elicits T cell responses that can prime for rapid antibody production and confer total protection upon viral challenge.

Authors:  Llilianne Ganges; Maritza Barrera; José Ignacio Núñez; Isabel Blanco; María Teresa Frias; Fernando Rodríguez; Francisco Sobrino
Journal:  Vaccine       Date:  2005-05-25       Impact factor: 3.641
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