Drug-drug and drug-disease interactions with nonsteroidal anti-inflammatory drugs.

Nonsteroidal anti-inflammatory drugs may cause a number of drug interactions. They can displace other drugs from serum proteins, and some can affect the metabolism or decrease the renal elimination of other drugs. In addition, they can attenuate the pharmacologic effect of other drugs, such as diuretic and antihypertensive agents, without affecting their disposition. Lastly, many disease states and aging can affect the handling of nonsteroidal anti-inflammatory drugs, mandating dose adjustment of some of these agents in certain clinical conditions. Some drugs may require more of these adjustments than others.