| Literature DB >> 35114043 |
Liming Peng1,2,3,4, Tianyi Long1, Fei Li2, Qiying Xie1,4.
Abstract
Cardiovascular diseases (CVDs) contribute to the leading cause of death worldwide. Despite significant improvements in CVDs diagnosis and treatment, a continued effort to explore novel therapeutic strategies is urgently need. N6-methyladenosine (m6 A) RNA methylation, well known as the most prevalent type of RNA modifications, involved in RNA stability, nuclear exports, translation, and decoy, plays a crucial role in the pathogenesis of a variety of diseases, including CVDs, cancer, and drug resistance. Here, our article summarizes cellular functions of m6 A modulators and recent research progress concerning the functions and mechanisms of m6 A methylation in CVDs, in hope of providing references for exploring novel therapeutic approaches and potential biomarkers in the treatment of CVDs.Entities:
Keywords: cardiovascular diseases; cellular functions; m6A methylation; mechanism
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Year: 2022 PMID: 35114043 DOI: 10.1002/cbin.11773
Source DB: PubMed Journal: Cell Biol Int ISSN: 1065-6995 Impact factor: 3.612