Literature DB >> 35114043

Emerging role of m6 A modification in cardiovascular diseases.

Liming Peng1,2,3,4, Tianyi Long1, Fei Li2, Qiying Xie1,4.   

Abstract

Cardiovascular diseases (CVDs) contribute to the leading cause of death worldwide. Despite significant improvements in CVDs diagnosis and treatment, a continued effort to explore novel therapeutic strategies is urgently need. N6-methyladenosine (m6 A) RNA methylation, well known as the most prevalent type of RNA modifications, involved in RNA stability, nuclear exports, translation, and decoy, plays a crucial role in the pathogenesis of a variety of diseases, including CVDs, cancer, and drug resistance. Here, our article summarizes cellular functions of m6 A modulators and recent research progress concerning the functions and mechanisms of m6 A methylation in CVDs, in hope of providing references for exploring novel therapeutic approaches and potential biomarkers in the treatment of CVDs.
© 2022 International Federation for Cell Biology.

Entities:  

Keywords:  cardiovascular diseases; cellular functions; m6A methylation; mechanism

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Year:  2022        PMID: 35114043     DOI: 10.1002/cbin.11773

Source DB:  PubMed          Journal:  Cell Biol Int        ISSN: 1065-6995            Impact factor:   3.612


  3 in total

1.  N6-methyladenosine methyltransferase KIAA1429 elevates colorectal cancer aerobic glycolysis via HK2-dependent manner.

Authors:  Ying Li; Liang He; Yingkai Wang; Yan Tan; Fan Zhang
Journal:  Bioengineered       Date:  2022-05       Impact factor: 6.832

2.  m6A regulator-mediated RNA methylation modification patterns are involved in immune microenvironment regulation of coronary heart disease.

Authors:  Zhaoshui Li; Yanjie Song; Meng Wang; Ruxin Shen; Kun Qin; Yu Zhang; Ting Jiang; Yifan Chi
Journal:  Front Cardiovasc Med       Date:  2022-08-25

3.  Bioinformatic analyses of the role of m6A RNA methylation regulators in abdominal aortic aneurysm.

Authors:  Changgeng Fu; Linghe Feng; Jiawei Zhang; Dajun Sun
Journal:  Ann Transl Med       Date:  2022-05
  3 in total

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