| Literature DB >> 35112312 |
Xiangyi Chen1,2,3, Dechen Yu1,2,3, Haiyu Zhou4,5,6, Xiaobo Zhang1,2,3, Yicun Hu1,2,3, Ruihao Zhang1,2,3, Xidan Gao1,2,3, Maoqiang Lin1,2,3, Taowen Guo1,2,3, Kun Zhang1,2,3.
Abstract
Ephrin receptor A7 (EphA7) is a member of the Eph receptor family. It is widely involved in signal transduction between cells, regulates cell proliferation and differentiation, and participates in developing neural tubes and brain. In addition, EphA7 also has a dual role of tumor promoter and tumor suppressor. It can participate in cell proliferation, migration and apoptosis through various mechanisms, and affect tumor differentiation, staging and prognosis. EphA7 may be a potential diagnostic marker and tumor treatment target. This article reviews the effects of EphA7 on a variety of tumor biological processes and pathological characteristics, as well as specific effects and regulatory mechanisms.Entities:
Keywords: Diagnostic markers; Ephrin receptor A7 (EphA7); Mechanism; Prognosis; Therapeutic target; Tumor
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Year: 2022 PMID： 35112312 DOI： 10.1007/s12094-022-02783-1
Source DB: PubMed Journal: Clin Transl Oncol ISSN： 1699-048X Impact factor: 3.405