| Literature DB >> 3511212 |
C J Taylor, A Hart, R M Batt, C McDougall, L McLean.
Abstract
A case of prolonged diarrhoea following Escherichia coli 0111 gastroenteritis is reported. Electron microscopy of the jejunal biopsy revealed effacement of the brush border and attachment of bacteria by pedestal formation. Specific activities of brush border enzymes showed marked depression of disaccharidases, zinc-resistant alpha-glucosidase, and alkaline phosphatase. In contrast, marker enzymes for basolateral membranes and endoplasmic reticulum were unaffected. The biochemical changes support the pathogenic mechanism suggested by ultrastructural studies previously reported.Entities:
Mesh:
Year: 1986 PMID: 3511212 DOI: 10.1097/00005176-198601000-00013
Source DB: PubMed Journal: J Pediatr Gastroenterol Nutr ISSN: 0277-2116 Impact factor: 2.839