Aziz Sümer1, Sebahattin Çelik2, Talar Vartanoğlu Aktokmakyan3, Çağhan Pekşen1, Osman Anıl Savaş1, Tutkun Talih4, Tunahan Sancak5, Yağmur Kuşçu5. 1. Department of General Surgery, İstinye University Faculty of Medicine, Gaziosmanpaşa Medical Park Hospital, İstanbul, Turkey. 2. Department of General Surgery, Yüzüncü Yıl University Faculty of Medicine, Van, Turkey. 3. Department of General Surgery, İstanbul Bağcılar Training and Research Hospital, İstanbul, Turkey. 4. Department of General Surgery, Erciyes University Faculty of Medicine, Kayseri, Turkey. 5. Yüzüncü Yıl University Faculty of Veterinary Medicine, Van, Turkey.
Abstract
OBJECTIVES: Obesity is a global health epidemic with considerable co-morbidities. The increasing demand for bariatric surgery has led to the emergence of new techniques. We modified previously described Mini Gastric By-pass(MGB) technique via leaving a bridge at the most cranial 2 cm of the fundus of the human stomach to the follow-up and treatment of the remnant stomach and duodenum. We would like to entitle this new technique as Bridged MGB and aimed to apply on rabbits as an experimental study. MATERIAL AND METHODS: The study was performed in the experimental animal laboratory of university after ethical approval was taken from the local ethics committee. Described new technique was applied to 2.1 and 3.2 kg 2 New Zealand rabbits. RESULTS: As a result of the operations, one of the rabbits died on the day of the operation; the other rabbit was exitus postoperatively on the third day. In autopsies, although no problem was detected at the anastomoses, necrosis was detected in the large curvature of both rabbits. CONCLUSION: Rabbit, one of the popular experimental animals, has been shown to be different from the human gastrointestinal system in both arterial and topographic aspects and it has been emphasized that it varies according to the species and even the diet and the climate. We believe that our study failed as a result of these differences and that animals more similar to humans should be used in gastrointestinal experimental studies.
OBJECTIVES: Obesity is a global health epidemic with considerable co-morbidities. The increasing demand for bariatric surgery has led to the emergence of new techniques. We modified previously described Mini Gastric By-pass(MGB) technique via leaving a bridge at the most cranial 2 cm of the fundus of the human stomach to the follow-up and treatment of the remnant stomach and duodenum. We would like to entitle this new technique as Bridged MGB and aimed to apply on rabbits as an experimental study. MATERIAL AND METHODS: The study was performed in the experimental animal laboratory of university after ethical approval was taken from the local ethics committee. Described new technique was applied to 2.1 and 3.2 kg 2 New Zealand rabbits. RESULTS: As a result of the operations, one of the rabbits died on the day of the operation; the other rabbit was exitus postoperatively on the third day. In autopsies, although no problem was detected at the anastomoses, necrosis was detected in the large curvature of both rabbits. CONCLUSION: Rabbit, one of the popular experimental animals, has been shown to be different from the human gastrointestinal system in both arterial and topographic aspects and it has been emphasized that it varies according to the species and even the diet and the climate. We believe that our study failed as a result of these differences and that animals more similar to humans should be used in gastrointestinal experimental studies.
Authors: Miguel Carbajo; Manuel García-Caballero; Miguel Toledano; Diego Osorio; Cándido García-Lanza; José Antonio Carmona Journal: Obes Surg Date: 2005-03 Impact factor: 4.129
Authors: Wayne J English; Eric J DeMaria; Stacy A Brethauer; Samer G Mattar; Raul J Rosenthal; John M Morton Journal: Surg Obes Relat Dis Date: 2017-12-16 Impact factor: 4.734