Yücel Yankol1, Cihan Karataş2, Turan Kanmaz2, Burak Koçak2, Münci Kalayoğlu2, Koray Acarlı3. 1. Transplant Center-Department of Surgery, Loyola University, Chicago Stritch School of Medicine, Maywood, IL, United States. 2. Organ Transplantion Center, Koç University Hospital, Istanbul, Turkey. 3. Organ Transplantion Center, Memorial Şişli Hospital, Istanbul, Turkey.
Abstract
OBJECTIVES: Living liver and kidney donor surgeries are major surgical procedures applied to healthy people with mortality and morbidity risks not providing any direct therapeutic advantage to the donor. In this study, we aimed to share our simultaneous and sequential living liver-kidney donor experience under literature review in this worldwide rare practice. MATERIAL AND METHODS: Between January 2007 and February 2018, a total of 1109 living donor nephrectomies and 867 living liver donor hepatectomies were performed with no mortality to living-related donors. Eight donors who were simultaneous or sequential living liver-kidney donors in this time period were retrospectively reviewed and presented with their minimum 2- year follow-up. RESULTS: Of the 8 donors, 3 of them were simultaneous and 5 of them were sequential liver-kidney donation. All of them were close relatives. Mean age was 39 (26-61) years and mean BMI was 25.7 (17.7-40). In 3 donors, right lobe, in 4 donors, left lateral sector, and in 1 donor, left lobe hepatectomy were performed. Median hospital stay was 9 (7-13) days. Two donors experienced early and late postoperative complications (Grade 3b and Grade 1). No mortality and no other long-term complication occurred. CONCLUSION: Expansion of the donor pool by utilizing grafts from living donors is a globally-accepted proposition since it provides safety and successful outcomes. Simultaneous or sequential liver and kidney donation from the same donor seems to be a reasonable option for combined liver-kidney transplant recipients in special circumstances with acceptable outcomes.
OBJECTIVES: Living liver and kidney donor surgeries are major surgical procedures applied to healthy people with mortality and morbidity risks not providing any direct therapeutic advantage to the donor. In this study, we aimed to share our simultaneous and sequential living liver-kidney donor experience under literature review in this worldwide rare practice. MATERIAL AND METHODS: Between January 2007 and February 2018, a total of 1109 living donor nephrectomies and 867 living liver donor hepatectomies were performed with no mortality to living-related donors. Eight donors who were simultaneous or sequential living liver-kidney donors in this time period were retrospectively reviewed and presented with their minimum 2- year follow-up. RESULTS: Of the 8 donors, 3 of them were simultaneous and 5 of them were sequential liver-kidney donation. All of them were close relatives. Mean age was 39 (26-61) years and mean BMI was 25.7 (17.7-40). In 3 donors, right lobe, in 4 donors, left lateral sector, and in 1 donor, left lobe hepatectomy were performed. Median hospital stay was 9 (7-13) days. Two donors experienced early and late postoperative complications (Grade 3b and Grade 1). No mortality and no other long-term complication occurred. CONCLUSION: Expansion of the donor pool by utilizing grafts from living donors is a globally-accepted proposition since it provides safety and successful outcomes. Simultaneous or sequential liver and kidney donation from the same donor seems to be a reasonable option for combined liver-kidney transplant recipients in special circumstances with acceptable outcomes.
Authors: M Nakamura; S Fuchinoue; I Nakajima; K Kitajima; T Tojimbara; K Takasaki; H Shiraga; K Ito; K Tanaka; T Agishi Journal: Nephrol Dial Transplant Date: 2001-01 Impact factor: 5.992
Authors: M Özbilgin; T Ünek; T Egeli; C Ağalar; S Ozkardesler; E Karadeniz; H Ellidokuz; F Obuz; I Astarcıoğlu Journal: Transplant Proc Date: 2017-04 Impact factor: 1.066
Authors: Abimereki D Muzaale; Nabil N Dagher; Robert A Montgomery; Sarah E Taranto; Maureen A McBride; Dorry L Segev Journal: Gastroenterology Date: 2011-11-19 Impact factor: 22.682