Literature DB >> 35109986

Loss of TET2 Tips the Scales Toward Tumorigenesis.

Brian C Capell1.   

Abstract

DNA methylation and demethylation function in the balance between cellular differentiation and cancer. Although the roles of DNA methyltransferases have been extensively explored in epidermal biology, ten-eleven translocation (TET) demethylase enzymes are poorly understood. In their new article in the Journal of Investigative Dermatology, Boudra et al. present evidence for a tumor-suppressive role of TET2 and its regulation of 5-hydroxymethylcytosine in the prevention of squamous cell carcinomas.
Copyright © 2021 The Author. Published by Elsevier Inc. All rights reserved.

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Year:  2022        PMID： 35109986      PMCID： PMC9128576          DOI： 10.1016/j.jid.2021.11.023

Source DB:  PubMed          Journal:  J Invest Dermatol        ISSN： 0022-202X            Impact factor:   7.590


  12 in total

1.  TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities.

Authors:  Sara Montagner; Cristina Leoni; Stefan Emming; Giulia Della Chiara; Chiara Balestrieri; Iros Barozzi; Viviana Piccolo; Susan Togher; Myunggon Ko; Anjana Rao; Gioacchino Natoli; Silvia Monticelli
Journal:  Cell Rep       Date:  2016-05-05       Impact factor: 9.423

2.  TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities.

Authors:  Sara Montagner; Cristina Leoni; Stefan Emming; Giulia Della Chiara; Chiara Balestrieri; Iros Barozzi; Viviana Piccolo; Susan Togher; Myunggon Ko; Anjana Rao; Gioacchino Natoli; Silvia Monticelli
Journal:  Cell Rep       Date:  2017-08-15       Impact factor: 9.423

Review 3.  The diverse roles of DNA methylation in mammalian development and disease.

Authors:  Maxim V C Greenberg; Deborah Bourc'his
Journal:  Nat Rev Mol Cell Biol       Date:  2019-08-09       Impact factor: 94.444

4.  Loss of the Epigenetic Mark 5-hmC in Psoriasis: Implications for Epidermal Stem Cell Dysregulation.

Authors:  Feng Li; Christine W Yuan; Shuyun Xu; Tingjian Zu; Yvon Woappi; Catherine A A Lee; Phammela Abarzua; Michael Wells; Matthew R Ramsey; Natasha Y Frank; Xunwei Wu; Anna Mandinova; Markus H Frank; Christine G Lian; George F Murphy
Journal:  J Invest Dermatol       Date:  2019-12-11       Impact factor: 8.551

5.  Dnmt3a and Dnmt3b Associate with Enhancers to Regulate Human Epidermal Stem Cell Homeostasis.

Authors:  Lorenzo Rinaldi; Debayan Datta; Judit Serrat; Lluis Morey; Guiomar Solanas; Alexandra Avgustinova; Enrique Blanco; José Ignacio Pons; David Matallanas; Alex Von Kriegsheim; Luciano Di Croce; Salvador Aznar Benitah
Journal:  Cell Stem Cell       Date:  2016-07-28       Impact factor: 24.633

6.  Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-γ.

Authors:  Lorenzo Rinaldi; Alexandra Avgustinova; Mercè Martín; Debayan Datta; Guiomar Solanas; Neus Prats; Salvador Aznar Benitah
Journal:  Elife       Date:  2017-04-20       Impact factor: 8.140

7.  Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin.

Authors:  Manuel Rodríguez-Paredes; Felix Bormann; Günter Raddatz; Julian Gutekunst; Carlota Lucena-Porcel; Florian Köhler; Elisabeth Wurzer; Katrin Schmidt; Stefan Gallinat; Horst Wenck; Joachim Röwert-Huber; Evgeniya Denisova; Lars Feuerbach; Jeongbin Park; Benedikt Brors; Esther Herpel; Ingo Nindl; Thomas G Hofmann; Marc Winnefeld; Frank Lyko
Journal:  Nat Commun       Date:  2018-02-08       Impact factor: 14.919

8.  Non-catalytic Roles of Tet2 Are Essential to Regulate Hematopoietic Stem and Progenitor Cell Homeostasis.

Authors:  Kyoko Ito; Joun Lee; Stephanie Chrysanthou; Yilin Zhao; Katherine Josephs; Hiroyo Sato; Julie Teruya-Feldstein; Deyou Zheng; Meelad M Dawlaty; Keisuke Ito
Journal:  Cell Rep       Date:  2019-09-03       Impact factor: 9.423

9.  DNMT1 maintains progenitor function in self-renewing somatic tissue.

Authors:  George L Sen; Jason A Reuter; Daniel E Webster; Lilly Zhu; Paul A Khavari
Journal:  Nature       Date:  2010-01-17       Impact factor: 49.962

10.  Genome wide DNA methylation profiling identifies specific epigenetic features in high-risk cutaneous squamous cell carcinoma.

Authors:  David Hervás-Marín; Faatiemah Higgins; Onofre Sanmartín; Jose Antonio López-Guerrero; M Carmen Bañó; J Carlos Igual; Inma Quilis; Juan Sandoval
Journal:  PLoS One       Date:  2019-12-20       Impact factor: 3.240
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