| Literature DB >> 35107458 |
Rohmad Yudi Utomo1, Atsushi Sugie2, Satoshi Okada1,3,4, Kazuki Miura1,3, Hiroyuki Nakamura1,3.
Abstract
Curcumin derivatives B and N were developed as disaggregation agents of amyloid β (Aβ) fibrils. The detoxification provided by each compound at a concentration of 1 μM was observed in neuroblastoma cells. Furthermore, both compounds significantly rescued locomotion dysfunction in an Aβ-expressing Drosophila model of Alzheimer's disease.Entities:
Mesh：
Substances：
Year: 2022 PMID： 35107458 DOI： 10.1039/d1cc07000b
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222