| Literature DB >> 35103964 |
Jiayi Pei1,2, Noortje A M van den Dungen3, Folkert W Asselbergs1,4,5, Michal Mokry1,3, Magdalena Harakalova6,7.
Abstract
Chromatin immunoprecipitation and sequencing (ChIP-seq) is a well-established method to study the epigenetic profile at the genome-wide scale, including histone modifications and DNA-protein interactions. It provides valuable insights to better understand disease mechanisms. Here we present an optimized ChIP-seq protocol suitable for human cardiac tissues, especially the frozen biobanked small biopsy samples.Entities:
Keywords: Antibody; Cardiac tissues; Chromatin immunoprecipitation; Enhancers; Promoters; Sequencing; Small biopsy
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Year: 2022 PMID： 35103964 DOI： 10.1007/978-1-0716-2140-0_6
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745