Yang Lan1,2,3, Shaowei Wu4,5,6. 1. Department of Occupational and Environmental Health, School of Public Health, Xi'an Jiaotong University Health Science Center, 76 Yanta West Road, Yanta District, Xi'an City, Shaanxi Province, 710061, People's Republic of China. 2. Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, Xi'an, Shaanxi, China. 3. Key Laboratory of Trace Elements and Endemic Diseases in Ministry of Health, Xi'an, Shaanxi, China. 4. Department of Occupational and Environmental Health, School of Public Health, Xi'an Jiaotong University Health Science Center, 76 Yanta West Road, Yanta District, Xi'an City, Shaanxi Province, 710061, People's Republic of China. shaowei_wu@xjtu.edu.cn. 5. Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, Xi'an, Shaanxi, China. shaowei_wu@xjtu.edu.cn. 6. Key Laboratory of Trace Elements and Endemic Diseases in Ministry of Health, Xi'an, Shaanxi, China. shaowei_wu@xjtu.edu.cn.
Abstract
PURPOSE OF REVIEW: With cardiovascular disease (CVD) being the top cause of deaths worldwide, it is important to ensure healthy cardiovascular aging through enhanced understanding and prevention of adverse health effects exerted by external factors. This review aims to provide an updated understanding of environmental influences on cardiovascular aging, by summarizing epidemiological and mechanistic evidence for the cardiovascular health impact of major environmental stressors, including air pollution, endocrine-disrupting chemicals (EDCs), metals, and climate change. RECENT FINDINGS: Recent studies generally support positive associations of exposure to multiple chemical environmental stressors (air pollution, EDCs, toxic metals) and extreme temperatures with increased risks of cardiovascular mortality and morbidity in the population. Environmental stressors have also been associated with a number of cardiovascular aging-related subclinical changes including biomarkers in the population, which are supported by evidence from relevant experimental studies. The elderly and patients are the most vulnerable demographic groups to majority environmental stressors. Future studies should account for the totality of individuals' exposome in addition to single chemical pollutants or environmental factors. Specific factors most responsible for the observed health effects related to cardiovascular aging remain to be elucidated.
PURPOSE OF REVIEW: With cardiovascular disease (CVD) being the top cause of deaths worldwide, it is important to ensure healthy cardiovascular aging through enhanced understanding and prevention of adverse health effects exerted by external factors. This review aims to provide an updated understanding of environmental influences on cardiovascular aging, by summarizing epidemiological and mechanistic evidence for the cardiovascular health impact of major environmental stressors, including air pollution, endocrine-disrupting chemicals (EDCs), metals, and climate change. RECENT FINDINGS: Recent studies generally support positive associations of exposure to multiple chemical environmental stressors (air pollution, EDCs, toxic metals) and extreme temperatures with increased risks of cardiovascular mortality and morbidity in the population. Environmental stressors have also been associated with a number of cardiovascular aging-related subclinical changes including biomarkers in the population, which are supported by evidence from relevant experimental studies. The elderly and patients are the most vulnerable demographic groups to majority environmental stressors. Future studies should account for the totality of individuals' exposome in addition to single chemical pollutants or environmental factors. Specific factors most responsible for the observed health effects related to cardiovascular aging remain to be elucidated.
Authors: Francesco Paneni; Candela Diaz Cañestro; Peter Libby; Thomas F Lüscher; Giovanni G Camici Journal: J Am Coll Cardiol Date: 2017-04-18 Impact factor: 24.094
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Authors: Carole H Sudre; Stefano Moriconi; Rafael Rehwald; Lorna Smith; Therese Tillin; Josephine Barnes; David Atkinson; Sébastien Ourselin; Nish Chaturvedi; Alun D Hughes; H Rolf Jäger; M Jorge Cardoso Journal: Front Cardiovasc Med Date: 2022-07-28