Ona Bloom1,2, Kevin J Tracey1,2, Valentin A Pavlov1,2. 1. The Feinstein Institutes for Medical Research, Northwell Health, Manhasset. 2. Donald and Barbara Zucker School of Medicine, Hempstead, New York, USA.
Abstract
PURPOSE OF REVIEW: To describe features and implications of chronic systemic inflammation in individuals with spinal cord injury (SCI) and to summarize the growing therapeutic possibilities to explore the vagus nerve-mediated inflammatory reflex in this context. RECENT FINDINGS: The discovery of the inflammatory reflex provides a rationale to explore neuromodulation modalities, that is, electrical vagus nerve stimulation and pharmacological cholinergic modalities to regulate inflammation after SCI. SUMMARY: Inflammation in individuals with SCI may negatively impact functional recovery and medical consequences after SCI. Exploring the potential of the vagus nerve-based inflammatory reflex to restore autonomic regulation and control inflammation may provide a novel approach for functional improvement in SCI.
PURPOSE OF REVIEW: To describe features and implications of chronic systemic inflammation in individuals with spinal cord injury (SCI) and to summarize the growing therapeutic possibilities to explore the vagus nerve-mediated inflammatory reflex in this context. RECENT FINDINGS: The discovery of the inflammatory reflex provides a rationale to explore neuromodulation modalities, that is, electrical vagus nerve stimulation and pharmacological cholinergic modalities to regulate inflammation after SCI. SUMMARY: Inflammation in individuals with SCI may negatively impact functional recovery and medical consequences after SCI. Exploring the potential of the vagus nerve-based inflammatory reflex to restore autonomic regulation and control inflammation may provide a novel approach for functional improvement in SCI.
Authors: B Bonaz; V Sinniger; D Hoffmann; D Clarençon; N Mathieu; C Dantzer; L Vercueil; C Picq; C Trocmé; P Faure; J-L Cracowski; S Pellissier Journal: Neurogastroenterol Motil Date: 2016-02-27 Impact factor: 3.598
Authors: Patrick D Ganzer; Michael J Darrow; Eric C Meyers; Bleyda R Solorzano; Andrea D Ruiz; Nicole M Robertson; Katherine S Adcock; Justin T James; Han S Jeong; April M Becker; Mark P Goldberg; David T Pruitt; Seth A Hays; Michael P Kilgard; Robert L Rennaker Journal: Elife Date: 2018-03-13 Impact factor: 8.140