| Literature DB >> 35101895 |
Rebecca R Crowther1,2,3,4, Stephanie M Schmidt1,4, Shannon M Lange1,2,4, Melanie C McKell1,2,4, Michelle C Robillard1,2,4, Junfang Zhao1,5, Wendy D Haffey6,7, Michael A Wyder6,7, Kenneth D Greis6,7, Kenneth D R Setchell1,5, Joseph E Qualls8,4.
Abstract
Metabolomics analyses suggest changes in amino acid abundance, particularly l-arginine (L-ARG), occur in patients with tuberculosis. Immune cells require L-ARG to fuel effector functions following infection. We have previously described an L-ARG synthesis pathway in immune cells; however, its role in APCs has yet to be uncovered. Using a coculture system with mycobacterial-specific CD4+ T cells, we show APC L-ARG synthesis supported T cell viability and proliferation, and activated T cells contained APC-derived L-ARG. We hypothesize that APCs supply L-ARG to support T cell activation under nutrient-limiting conditions. This work expands the current model of APC-T cell interactions and provides insight into the effects of nutrient availability in immune cells.Entities:
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Year: 2022 PMID： 35101895 PMCID： PMC8820592 DOI： 10.4049/jimmunol.2100652
Source DB: PubMed Journal: J Immunol ISSN： 0022-1767 Impact factor: 5.422