| Literature DB >> 35101090 |
Haoran Wang1, Keqin Zhang1,2, Zheng Ruan1,3, Dingqi Sun1,2, Hui Zhang1,2, Guiting Lin4, Liangliang Hu5, Shengtian Zhao6,7, Qiang Fu8,9.
Abstract
Entities:
Year: 2022 PMID: 35101090 PMCID: PMC8805320 DOI: 10.1186/s13287-022-02727-0
Source DB: PubMed Journal: Stem Cell Res Ther ISSN: 1757-6512 Impact factor: 6.832
Fig. 2Changes of microenvironment and activation of Nrf2/HO-1 pathway in corpus cavernosum. A Masson’s trichrome staining was performed to assess the corporal fibrosis level in rat cavernous of all the three groups after different treatment (the area of smooth muscle is represented by red stain and the area of collagen by blue stain). B Representative immunohistochemical staining of vWF-positive smooth muscle (green) in Sham, DM, M, P + M Groups. C Representative immunohistochemical staining of α-SMA-positive smooth muscle (green) in Sham, DM, M, P + M Groups. D The expression of Nrf2 and HO-1 protein was observed at different time points among the groups.β-Actin was used as a loading control. E Effect of MSCs and/or probucol treatment on the ratio of smooth muscle to collagen in the corpus cavernosum in 2 weeks. Bars denote the mean densitometry ratio between smooth muscle content and collagen content per field. **p < 0.01 indicates significant difference compared with Sham Group. #p < 0.05 and ##p < 0.01 indicate significant difference compared with the DM Group