Literature DB >> 35099804

Synthesis of Phthaladyn-29 and Naphthalimide-10, GTP Site Directed Dynamin GTPase Inhibitors.

Cecilia C Russell1, Kate L Prichard1, Nicholas S O'Brien1, Adam McCluskey1, Phillip J Robinson2, Jennifer R Baker3.   

Abstract

Herein we describe the detailed synthesis of the dynamin inhibitors Phthaladyn-29 and Napthaladyn-10, and their chemical scaffold matched partner inactive compounds. Combined with the assay data provided, this allows the interrogation of dynamin in vitro and potentially in vivo.
© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Chemical probe; Chemical synthesis; Dynamin inhibitors; Endocytosis; Naphthalimide; Phthaladyn

Mesh：

Substances：

Year:  2022        PMID： 35099804     DOI： 10.1007/978-1-0716-1916-2_18

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  24 in total

Review 1.  From endocytosis to membrane fusion: emerging roles of dynamin in virus entry.

Authors:  Yeping Sun; Po Tien
Journal:  Crit Rev Microbiol       Date:  2012-06-28       Impact factor: 7.624

2.  Dynamin forms a Src kinase-sensitive complex with Cbl and regulates podosomes and osteoclast activity.

Authors:  Angela Bruzzaniti; Lynn Neff; Archana Sanjay; William C Horne; Pietro De Camilli; Roland Baron
Journal:  Mol Biol Cell       Date:  2005-05-04       Impact factor: 4.138

3.  Agonist-dependent endocytosis of γ-aminobutyric acid type A (GABAA) receptors revealed by a γ2(R43Q) epilepsy mutation.

Authors:  Severine Chaumont; Caroline André; David Perrais; Eric Boué-Grabot; Antoine Taly; Maurice Garret
Journal:  J Biol Chem       Date:  2013-08-09       Impact factor: 5.157

Review 4.  Targeting membrane trafficking in infection prophylaxis: dynamin inhibitors.

Authors:  Callista B Harper; Michel R Popoff; Adam McCluskey; Phillip J Robinson; Frédéric A Meunier
Journal:  Trends Cell Biol       Date:  2012-11-17       Impact factor: 20.808

5.  Osteoblast differentiation and migration are regulated by dynamin GTPase activity.

Authors:  Pierre P Eleniste; Su Huang; Kornchanok Wayakanon; Heather W Largura; Angela Bruzzaniti
Journal:  Int J Biochem Cell Biol       Date:  2013-10-26       Impact factor: 5.085

Review 6.  Dynamin, a membrane-remodelling GTPase.

Authors:  Shawn M Ferguson; Pietro De Camilli
Journal:  Nat Rev Mol Cell Biol       Date:  2012-01-11       Impact factor: 94.444

Review 7.  Insights into the novel three 'D's of epilepsy treatment: drugs, delivery systems and devices.

Authors:  Shadab A Pathan; Gaurav K Jain; Sohail Akhter; Divya Vohora; Farhan J Ahmad; Roop K Khar
Journal:  Drug Discov Today       Date:  2010-08-05       Impact factor: 7.851

8.  Role of dynamin, synaptojanin, and endophilin in podocyte foot processes.

Authors:  Keita Soda; Daniel M Balkin; Shawn M Ferguson; Summer Paradise; Ira Milosevic; Silvia Giovedi; Laura Volpicelli-Daley; Xuefei Tian; Yumei Wu; Hong Ma; Sung Hyun Son; Rena Zheng; Gilbert Moeckel; Ottavio Cremona; Lawrence B Holzman; Pietro De Camilli; Shuta Ishibe
Journal:  J Clin Invest       Date:  2012-11-26       Impact factor: 14.808

9.  A missense mutation in a highly conserved alternate exon of dynamin-1 causes epilepsy in fitful mice.

Authors:  Rebecca M Boumil; Verity A Letts; Monica C Roberts; Christine Lenz; Connie L Mahaffey; Zhong-Wei Zhang; Tobias Moser; Wayne N Frankel
Journal:  PLoS Genet       Date:  2010-08-05       Impact factor: 5.917

10.  Uromodulin upregulates TRPV5 by impairing caveolin-mediated endocytosis.

Authors:  Matthias T F Wolf; Xue-Ru Wu; Chou-Long Huang
Journal:  Kidney Int       Date:  2013-03-06       Impact factor: 10.612
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