| Literature DB >> 35099085 |
Juliana R Gubiani1, Darlon I Bernardi1, Caio C P De Paula2,3, Mirna H R Seleghim2, Antonio G Ferreira4, Andrea N L Batista5, João M Batista6, Lucianne F P Oliveira7, Simone P Lira7, Joanna E Burdette8, Roberto G S Berlinck1.
Abstract
Microbial strains isolated from extreme and understudied environments, such as caves, are still poorly investigated for the production of bioactive secondary metabolites. Investigation of the ethyl acetate extract from the growth medium produced by the soil-derived fungus Aspergillus sp. SDC28, isolated from a Brazilian cave, yielded two anthraquinones: versicolorin C (1) and versiconol (2). The complete assignment of nuclear magnetic resonance and mass spectroscopic data of 1 and 2 was performed for the first time. Moreover, the yet unreported absolute configuration of both compounds was unambiguously established by analysis of experimental and theoretical electronic circular dichroism data. Vibrational circular dichroism was also applied to confirm the absolute stereochemistry of 2. Compounds 1 and 2 showed cytotoxic activity against human ovarian cancer cells (OVCAR3).Entities:
Keywords: anticancer; aromatic metabolites; extremophiles; polyketides; soil-derived fungus
Mesh：
Substances：
Year: 2022 PMID： 35099085 PMCID： PMC8983557 DOI： 10.1002/ardp.202100441
Source DB: PubMed Journal: Arch Pharm (Weinheim) ISSN： 0365-6233 Impact factor: 3.751