BACKGROUND: Estimates indicate that nearly eight percent of the over 500,000 survivors of childhood cancer living in the United States are frail in their fourth and fifth decades of life, a phenotype typically seen in geriatric populations. Participation in regular physical activity to improve physical fitness in healthy and diseased populations reduces risk for frail health by increasing physiologic reserve. However, physical activity may not have the same effects on fitness in childhood cancer survivors as it does among their peers with no cancer history. AIMS: This scoping review seeks to describe associations between physical activity, physical fitness, chronic disease, and mortality in childhood cancer survivors. METHODS: Relevant literature was identified through a comprehensive search in the PubMed, Web of Science, CINAHL, and Cochrane databases. A narrative synthesis was performed on observational studies that had physical activity or physical fitness clearly defined and compared with chronic disease outcomes. RESULTS: A total of 595 studies were screened, and results from 11 studies are presented. Childhood cancer survivors who participate in regular physical activity have improved markers of cardiovascular health, decreased risk of overt cardiovascular disease, and decreased risk of all-cause mortality compared to survivors who are not physically active. Childhood cancer survivors who are physically fit have increased neurocognition, and decreased risk of all-cause mortality compared to survivor's who are not fit. The differential effects of physical activity on fitness and health among childhood cancer survivors when compared to peers is potentially related to treatment exposures that damage cardiovascular tissue and impact regenerative potential. CONCLUSION: Research is needed to determine the optimal timing, frequency, intensity, and duration of physical activity necessary to optimize fitness in childhood cancer survivors.
BACKGROUND: Estimates indicate that nearly eight percent of the over 500,000 survivors of childhood cancer living in the United States are frail in their fourth and fifth decades of life, a phenotype typically seen in geriatric populations. Participation in regular physical activity to improve physical fitness in healthy and diseased populations reduces risk for frail health by increasing physiologic reserve. However, physical activity may not have the same effects on fitness in childhood cancer survivors as it does among their peers with no cancer history. AIMS: This scoping review seeks to describe associations between physical activity, physical fitness, chronic disease, and mortality in childhood cancer survivors. METHODS: Relevant literature was identified through a comprehensive search in the PubMed, Web of Science, CINAHL, and Cochrane databases. A narrative synthesis was performed on observational studies that had physical activity or physical fitness clearly defined and compared with chronic disease outcomes. RESULTS: A total of 595 studies were screened, and results from 11 studies are presented. Childhood cancer survivors who participate in regular physical activity have improved markers of cardiovascular health, decreased risk of overt cardiovascular disease, and decreased risk of all-cause mortality compared to survivors who are not physically active. Childhood cancer survivors who are physically fit have increased neurocognition, and decreased risk of all-cause mortality compared to survivor's who are not fit. The differential effects of physical activity on fitness and health among childhood cancer survivors when compared to peers is potentially related to treatment exposures that damage cardiovascular tissue and impact regenerative potential. CONCLUSION: Research is needed to determine the optimal timing, frequency, intensity, and duration of physical activity necessary to optimize fitness in childhood cancer survivors.
Authors: Emanuele Di Angelantonio; Pei Gao; Lisa Pennells; Stephen Kaptoge; Muriel Caslake; Alexander Thompson; Adam S Butterworth; Nadeem Sarwar; David Wormser; Danish Saleheen; Christie M Ballantyne; Bruce M Psaty; Johan Sundström; Paul M Ridker; Dorothea Nagel; Richard F Gillum; Ian Ford; Pierre Ducimetiere; Stefan Kiechl; Wolfgang Koenig; Robin P F Dullaart; Gerd Assmann; Ralph B D'Agostino; Gilles R Dagenais; Jackie A Cooper; Daan Kromhout; Altan Onat; Robert W Tipping; Agustín Gómez-de-la-Cámara; Annika Rosengren; Susan E Sutherland; John Gallacher; F Gerry R Fowkes; Edoardo Casiglia; Albert Hofman; Veikko Salomaa; Elizabeth Barrett-Connor; Robert Clarke; Eric Brunner; J Wouter Jukema; Leon A Simons; Manjinder Sandhu; Nicholas J Wareham; Kay-Tee Khaw; Jussi Kauhanen; Jukka T Salonen; William J Howard; Børge G Nordestgaard; Angela M Wood; Simon G Thompson; S Matthijs Boekholdt; Naveed Sattar; Chris Packard; Vilmundur Gudnason; John Danesh Journal: JAMA Date: 2012-06-20 Impact factor: 56.272
Authors: Stéphanie A Prince; Kristi B Adamo; Meghan E Hamel; Jill Hardt; Sarah Connor Gorber; Mark Tremblay Journal: Int J Behav Nutr Phys Act Date: 2008-11-06 Impact factor: 6.457
Authors: Nickhill Bhakta; Qi Liu; Kirsten K Ness; Malek Baassiri; Hesham Eissa; Frederick Yeo; Wassim Chemaitilly; Matthew J Ehrhardt; Johnnie Bass; Michael W Bishop; Kyla Shelton; Lu Lu; Sujuan Huang; Zhenghong Li; Eric Caron; Jennifer Lanctot; Carrie Howell; Timothy Folse; Vijaya Joshi; Daniel M Green; Daniel A Mulrooney; Gregory T Armstrong; Kevin R Krull; Tara M Brinkman; Raja B Khan; Deo K Srivastava; Melissa M Hudson; Yutaka Yasui; Leslie L Robison Journal: Lancet Date: 2017-09-08 Impact factor: 79.321