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Literature DB >> 3509785

Low serum osteocalcin in acute alcohol intoxication: a direct toxic effect of alcohol on osteoblasts.

H Rico¹, J A Cabranes, J Cabello, F Gómez-Castresana, E R Hernández.

Abstract

A direct effect of alcohol on bone cells has not been convincingly demonstrated, but numerous studies have postulated that alcohol inhibits osteoblastic activity. Since osteoblasts synthesize osteocalcin, we studied the serum levels of this protein in 15 patients with acute alcoholic intoxication to determine if alcohol has an effect on these cells, whether direct or indirect. We found lower osteocalcin levels in our alcoholics than in 15 normal individuals of similar age and sex (3.1 +/- 1.0 vs. 6.6 +/- 0.8 ng/ml; P less than 0.0001), evidence of the influence of alcohol on osteoblasts. This effect seems to be direct rather than mediated.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 1987 PMID： 3509785

Source DB: PubMed Journal: Bone Miner ISSN： 0169-6009

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Cited

12 in total

1. Alcoholism-associated spinal and femoral bone loss in abstinent male alcoholics, as measured by dual X-ray absorptiometry.

Authors: K S Chon; D J Sartoris; S A Brown; P Clopton
Journal: Skeletal Radiol Date: 1992 Impact factor: 2.199

2. Alcohol decreases serum osteocalcin in a dose-dependent way in normal subjects.

Authors: H K Nielsen; L Lundby; K Rasmussen; P Charles; C Hansen
Journal: Calcif Tissue Int Date: 1990-03 Impact factor: 4.333

3. Alcohol and bone mineral density.

Authors: H Rico
Journal: BMJ Date: 1993-10-09

4. Twelve months of voluntary heavy alcohol consumption in male rhesus macaques suppresses intracortical bone remodeling.

Authors: Gino W Gaddini; Kathleen A Grant; Andrew Woodall; Cara Stull; Gianni F Maddalozzo; Bo Zhang; Russell T Turner; Urszula T Iwaniec
Journal: Bone Date: 2014-11-07 Impact factor: 4.398

5. Chronic alcohol ingestion induces osteoclastogenesis and bone loss through IL-6 in mice.

Authors: J Dai; D Lin; J Zhang; P Habib; P Smith; J Murtha; Z Fu; Z Yao; Y Qi; E T Keller
Journal: J Clin Invest Date: 2000-10 Impact factor: 14.808

Review 6. Alcohol and bone.

Authors: K Laitinen; M Välimäki
Journal: Calcif Tissue Int Date: 1991 Impact factor: 4.333

Low serum osteocalcin in acute alcohol intoxication: a direct toxic effect of alcohol on osteoblasts.

1. Alcoholism-associated spinal and femoral bone loss in abstinent male alcoholics, as measured by dual X-ray absorptiometry.

2. Alcohol decreases serum osteocalcin in a dose-dependent way in normal subjects.

3. Alcohol and bone mineral density.

4. Twelve months of voluntary heavy alcohol consumption in male rhesus macaques suppresses intracortical bone remodeling.

5. Chronic alcohol ingestion induces osteoclastogenesis and bone loss through IL-6 in mice.

Review 6. Alcohol and bone.

7. Evidence of degraded BMD and geometry at the proximal femora in male patients with alcoholic liver cirrhosis.

Review 8. Aetiologies of male osteoporosis: identification procedures.

9. Bone histomorphometry, bone mass, and related parameters in alcoholic males.

10. Association of serum intact parathyroid hormone with lower estimated glomerular filtration rate.