Successful management of delirium with dexmedetomidine in a patient with haloperidol-induced neuroleptic malignant syndrome: A case report.

BACKGROUND: We report a case of lorazepam-induced agitated delirium treated with haloperidol, which in turn triggered the onset of neuroleptic malignant syndrome (NMS). The latter condition, a medical emergency, was effectively treated with medical treatment and dexmedetomidine, a versatile and highly selective short-acting alpha-2 adrenergic agonist with sedative-hypnotic and anxiolytic effects. CASE
SUMMARY: A 65-year-old man with a history of bipolar disorder presented to the emergency department with severe abdominal discomfort after binge eating. During his hospital stay, he received intravenous lorazepam for insomnia. On the next day, he became delirious and was thus treated with seven doses (5 mg each) of haloperidol over a 48 h period. Signs of NMS (hyperthermia, rigidity, myoclonus of upper limbs, impaired consciousness, tachypnea, and dark urine) became apparent and haloperidol was immediately suspended and brisk diuresis was initiated. On intensive care unit admission, he was confused, disoriented, and markedly agitated. Dexmedetomidine infusion was started with the goal of achieving a Richmond Agitation-Sedation Scale score of -1 or 0. NMS was resolved gradually and the patient stabilized, permitting discontinuation of dexmedetomidine after 3 d.
CONCLUSION: Dexmedetomidine may be clinically helpful for the management of NMS, most likely because of its sympatholytic activity. ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.

Core Tip: Neuroleptic malignant syndrome (NMS), a life-threatening condition characterized by hyperthermia, rigidity, altered mental status, and dysautonomia, can occur in 0.02%–3% of patients who receive haloperidol. Herein, we report a case of lorazepam-induced agitated delirium treated with haloperidol, which further triggered NMS. The NMS was effectively managed with medical therapy and dexmedetomidine, a versatile and highly selective short-acting alpha-2 adrenergic agonist with sedative-hypnotic and anxiolytic effects. Dexmedetomidine may be clinically helpful for the management of NMS because of its sympatholytic activity. In the presence of rapid shallow breathing, dexmedetomidine may provide better patient comfort with less respiratory depression than does propofol.

INTRODUCTION

Delirium, a transient, reversible organic mental syndrome characterized by disorganized thinking and altered consciousness, commonly occurs in acutely hospitalized elderly patients[1]. Hospital-acquired delirium can be triggered by certain drugs administered upon admission or during the patient’s stay, including benzodiazepines[2]. While haloperidol is a commonly accepted first-line treatment against agitated delirium[3], the risk of serious adverse events is not negligible. Among them, neuroleptic malignant syndrome (NMS), a life-threatening condition characterized by hyperthermia, severe muscle rigidity, altered mental status, and autonomic dysfunction, can occur in 0.02%–3% of all patients who receive haloperidol[4]. The clinical management of NMS poses major challenges, but intensive care unit (ICU) medications are emerging as part of the therapeutic armamentarium[5].

Herein, we report a case of lorazepam-induced agitated delirium treated with haloperidol, which in turn triggered the onset of NMS. The latter condition, a medical emergency, was effectively managed with medical treatment and dexmedetomidine, a versatile and highly selective short-acting alpha-2 adrenergic agonist with sedative-hypnotic and anxiolytic effects[6]. Because extreme sympathetic nervous system activation is involved in the pathophysiology of NMS[7], we hypothesized that dexmedetomidine may be clinically beneficial for managing this medical emergency because of its sympatholytic activity[8].

CASE PRESENTATION

Chief complaints

A 65-year-old man presented to the emergency department with severe abdominal discomfort after binge eating.

History of present illness

Because of food impaction, oral intake and medications were discontinued. However, lorazepam was administered intravenously to treat insomnia. The next day, the patient became delirious and was thus treated with seven doses (5 mg each) of haloperidol over a 48 h period. Unfortunately, he developed hyperthermia (body temperature: 40.6 °C) accompanied by tachypnea (respiratory rate: 40 breaths per min), tachycardia (heart rate: 128 beats per min), impaired consciousness, muscle rigidity, and dark urine. The serum creatine kinase (CK) levels were markedly increased (1910 U/L) (Figure 1), indicating rhabdomyolysis. NMS was diagnosed, and haloperidol was immediately stopped. Adequate hydration and body cooling were implemented; additionally, bromocriptine (2.5 mg/3 times daily) and transdermal patches containing rotigotine (2 mg/24 h) were applied to overcome the hypodopaminergic state. The patient was subsequently transferred to the ICU for intensive monitoring and treatment of NMS.

Figure 1

Time course of haloperidol administration (Black arrow: 15 mg; white arrow: 10 mg) and dexmedetomidine infusion in relation to changes in BT and serum CK levels. BT: Body temperature; CK: Creatine kinase.

History of past illness

The patient’s medical history was notable for bipolar disorder, and his medications included trihexyphenidyl, quetiapine, flupentixol, and flunitrazepam.

Personal and family history

Bipolar disorder.

Physical examination

Upon initial evaluation, the patient’s temperature was 36 °C, the heart rate 102 beats per min, and the respiratory rate 20 breaths per min. A physical examination revealed abdominal tension.

Laboratory examinations

The laboratory findings upon ICU admission were as follows: CK, 21000 U/L; blood urea nitrogen, 29 mg/dL; creatinine, 1.4 mg/dL; potassium, 4.5 mEq/L; blood pH, 7.4; PCO2, 31 mmHg; PO2, 70 mmHg; HCO3, 23 mEq/L; and base excess, -1.5 mmol/L.

Imaging examinations

Computed tomography revealed food impaction accompanied by bowel distension from the esophagus to the small intestine (Figure 2).

Figure 2

Abdominal computed tomography findings. Digestive tract distension was shown from the esophagus to the small bowel.

FINAL DIAGNOSIS

Lorazepam-induced delirium treated with haloperidol, which in turn triggered NMS.

TREATMENT

On ICU admission, the patient was confused and disoriented to time, space, situation, and persons. His Glasgow coma score (GCS) was 13 (Eye 4, Motor 5, and Verbal 4) and papillary light reflexes were bilaterally positive. Severe rigidity and myoclonus (especially in the upper extremities) were evident. Additionally, the patient was severely agitated (Richmond Agitation-Sedation Scale (RASS)[9] score = 3), and made attempts at removing his intravenous catheter and nasogastric tube. In addition to continuation of medical management, dexmedetomidine infusion was started (initial rate: 0.2 µg/kg/h) with the goal of achieving a RASS score of -1 or 0. Owing to persistent agitation (accompanied by shouting and attempts to remove restraints), dexmedetomidine dosing was further increased to 0.5 µg/kg/h. Gradual resolution of muscle rigidity, myoclonus, and agitation was observed over the next day (GCS score: 14). Thus, the dosage of dexmedetomidine was lowered to 0.3 µg/kg/h. The family’s presence at the patient’s bed side was encouraged. Containment measures were removed and the dexmedetomidine dosing was further reduced. Full cooperation was achieved 72 h after the initial infusion of dexmedetomidine, which was thus discontinued. After full regression of rhabdomyolysis and rigidity, the patient was transferred to the general ward for further care. Figure 3 depicts the timeline of the main clinical events.

Figure 3

Timeline depicting the onset of lorazepam-induced delirium followed by the development of neuroleptic malignant syndrome. CK: Creatine kinase; RASS: Richmond agitation-sedation scale; ICU: Intensive care unit.

OUTCOME AND FOLLOW-UP

The patient did not present additional episodes of delirium and was successfully discharged 18 d after admission. He is currently undergoing regular follow-up at our psychiatric clinic.

DISCUSSION

We describe a complex case of lorazepam-induced delirium occurring in an elderly hospitalized patient who was admitted for food impaction. Treatment of delirium with haloperidol precipitated the onset of NMS, an uncommon, yet life-threatening, complication of antipsychotics. Early diagnosis and removal of precipitating agents are very important in the management of NMS. NMS was managed with dexmedetomidine, an ICU drug, which successfully corrected autonomic instability. Clinical improvement was observed within a few days and the patient was successfully discharged 18 d after admission. Our case provides an illustrative example of how polypharmacotherapy in acutely hospitalized elderly patients can give rise to medical emergencies requiring ICU care.

Benzodiazepines are a common cause of drug-induced delirium. In the elderly, because of the decreased renal clearance and other age-related pharmacodynamic and pharmacokinetic changes, these drugs can accumulate and cause toxicity and delirium[10]. Our patient became delirious after in-hospital administration of lorazepam for insomnia. Although the mechanisms of benzodiazepine-induced delirium are not well defined, neurotransmitter imbalances with excess brain dopaminergic activity are common in delirious patients[10,11]. Importantly, while medications can induce delirium, they may also be used to manage its symptoms[10]. Owing to their antidopaminergic effects, typical antipsychotics like haloperidol are commonly used in managing delirium[3]. As in our patient, haloperidol can be given at multiple doses (2–5 mg every 15–30 min) until clinical improvement is achieved[12]. However, the use of haloperidol for managing delirium in our case precipitated the onset of NMS, possibly as a result of excess dopamine D2 receptor blockade in the hypothalamic, nigrostriatal, mesolimbic, and mesocortical pathways[13].

Once NMS is diagnosed, ICU drugs like dexmedetomidine or propofol are potentially effective management options[14,15]. Because extreme sympathetic nervous system activation is involved in the pathophysiology of NMS[7], we reasoned that dexmedetomidine may be helpful in the management of this medical emergency because of its sympatholytic activity[8]. In the presence of rapid shallow breathing as in our case, dexmedetomidine may also provide better patient comfort with less respiratory depression than does propofol[16]. Importantly, dexmedetomidine also suppresses the spontaneous firing rate of locus coeruleus neurons and decreases heat generation by alpha-2 adrenergic receptor blockade in the hypothalamus[17]. Hence, it can successfully correct the profound thermogenesis and hypermetabolism typical of NMS as it did in our patient. While recommendations for specific treatments in NMS continue to be based on small-sized studies and clinical experience, this case serves as a useful reminder to clinicians to consider dexmedetomidine as part of the current therapeutic armamentarium.

CONCLUSION

Dexmedetomidine may be clinically beneficial for managing NMS because of its sympatholytic activity and its capacity to reduce heat generation. In the presence of rapid shallow breathing, dexmedetomidine may also provide better patient comfort with less respiratory depression than does propofol.