Literature DB >> 35094345

Charge-Based Multiarm Avidin Nanoconstruct as a Platform Technology for Applications in Drug Delivery.

Tengfei He1, Chenzhen Zhang1, Ambika G Bajpayee2,3.   

Abstract

Here we describe methods for synthesizing cationic multiarm Avidin (mAv) nanoconstruct that has a wide range of applications in drug delivery and imaging for a variety of negatively charged tissues. The multiarm structure provides multiple sites for covalent conjugation of drugs. We use avidin-biotin reaction that gives the flexibility for conjugating any desired biotinylated drug to mAv by simple mixing at room temperature. We also describe methods to control hydrolysis rates of ester linkers to enable sustained (and tunable) drug release rates in therapeutic doses.
© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Avidin; Bioelectrostatics; Biotin; Cartilage; Drug delivery; Negatively charged tissues; PEGs

Mesh：

Substances：

Year:  2022        PMID： 35094345     DOI： 10.1007/978-1-0716-1811-0_28

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  9 in total

1.  Avidin as a model for charge driven transport into cartilage and drug delivery for treating early stage post-traumatic osteoarthritis.

Authors:  Ambika G Bajpayee; Cliff R Wong; Moungi G Bawendi; Eliot H Frank; Alan J Grodzinsky
Journal:  Biomaterials       Date:  2013-10-10       Impact factor: 12.479

2.  Electrostatic interactions enable rapid penetration, enhanced uptake and retention of intra-articular injected avidin in rat knee joints.

Authors:  Ambika G Bajpayee; Maximiliano Scheu; Alan J Grodzinsky; Ryan M Porter
Journal:  J Orthop Res       Date:  2014-04-21       Impact factor: 3.494

Review 3.  Multi-scale imaging techniques to investigate solute transport across articular cartilage.

Authors:  Behdad Pouran; Vahid Arbabi; Ambika G Bajpayee; Jasper van Tiel; Juha Töyräs; Jukka S Jurvelin; Jos Malda; Amir A Zadpoor; Harrie Weinans
Journal:  J Biomech       Date:  2018-06-22       Impact factor: 2.712

4.  Sustained intra-cartilage delivery of low dose dexamethasone using a cationic carrier for treatment of post traumatic osteoarthritis.

Authors:  A J Grodzinsky; R M Porter; A G Bajpayee; R E De la Vega; M Scheu; N H Varady; I A Yannatos; L A Brown; Y Krishnan; T J Fitzsimons; P Bhattacharya; E H Frank
Journal:  Eur Cell Mater       Date:  2017-12-05       Impact factor: 3.942

5.  A rabbit model demonstrates the influence of cartilage thickness on intra-articular drug delivery and retention within cartilage.

Authors:  Ambika G Bajpayee; Maximiliano Scheu; Alan J Grodzinsky; Ryan M Porter
Journal:  J Orthop Res       Date:  2015-03-18       Impact factor: 3.494

6.  Multi-arm Avidin nano-construct for intra-cartilage delivery of small molecule drugs.

Authors:  Tengfei He; Chenzhen Zhang; Armin Vedadghavami; Shikhar Mehta; Heather A Clark; Ryan M Porter; Ambika G Bajpayee
Journal:  J Control Release       Date:  2019-12-13       Impact factor: 9.776

7.  Cartilage penetrating cationic peptide carriers for applications in drug delivery to avascular negatively charged tissues.

Authors:  Armin Vedadghavami; Erica K Wagner; Shikhar Mehta; Tengfei He; Chenzhen Zhang; Ambika G Bajpayee
Journal:  Acta Biomater       Date:  2018-12-06       Impact factor: 8.947

Review 8.  Cartilage-targeting drug delivery: can electrostatic interactions help?

Authors:  Ambika G Bajpayee; Alan J Grodzinsky
Journal:  Nat Rev Rheumatol       Date:  2017-02-09       Impact factor: 20.543

9.  A direct spectrophotometric microassay for sulfated glycosaminoglycans in cartilage cultures.

Authors:  R W Farndale; C A Sayers; A J Barrett
Journal:  Connect Tissue Res       Date:  1982       Impact factor: 3.417
  9 in total

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