K Zhan1,2, X Zhang3, B Wang4, Z Jiang5, X Fang1,2, S Yang6, H Jia1, L Li7, G Cao7, K Zhang8, X Ma2. 1. From the College of Public Health, Southwest Medical University, Luzhou, Sichuan, China. 2. Department of Epidemiology, College of Preventive Medicine, Third Military Medical University (Army Medical University), Chongqing, China. 3. Department of General Surgery, Daping Hospital, Third Military Medical University (Army Medical University), Chongqing, China. 4. Pulmonary and Critical Care Medicine Center, Chinese PLA Respiratory Disease Institute, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, China. 5. Yidu Cloud Technology Co. Ltd, Beijing, China. 6. Department of Infectious Diseases, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China. 7. Department of Respiratory Medicine, Daping Hospital, Third Military Medical University (Army Medical University), Chongqing, China. 8. Department of Outpatients, Daping Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
Abstract
BACKGROUND AND AIM: To systematically evaluate the associations between glycemic control and short- to long-term outcomes in coronavirus disease 2019 (COVID-19) patients with type 2 diabetes (T2D). DESIGN AND METHODS: A multi-center prospective cohort study including 574 COVID-19 patients with T2D was conducted in Wuhan, China. All patients were followed-up 1 year after hospital discharge using a uniformed questionnaire including self-reported symptoms, and the chronic obstructive pulmonary disease assessment test items. RESULTS: Of the 574 patients, 443 (77.2%) had well-controlled blood glucose. Glycemic control was significantly associated with decreased risk of death [odds ratio (OR) 0.24, 95% confidence interval (CI) 0.10-0.57], intensive care unit admission (OR 0.22, 95% CI 0.10-0.49), invasive mechanical ventilation (OR 0.25, 95% CI 0.08-0.72), disease progression (OR 0.25, 95% CI 0.11-0.55), and composite outcome (OR 0.26, 95% CI 0.14-0.49). The top five long-term sequelae include fatigue (31.5%), sweating (21.2%), chest tightness (15.1%), anxiety (12.2%), myalgia (10.6%) and short breath (6.4%). Glycemic control was associated with decreased risk of respiratory sequelae (OR 0.42, 95% CI 0.18-0.99; P = 0.048). CONCLUSIONS: Glycemic control was significantly associated with short-term outcomes in COVID-19 patients with T2D and showed a significant association with long-term respiratory sequelae. The management and control of blood glucose has a positive impact on prognosis of COVID-19.
BACKGROUND AND AIM: To systematically evaluate the associations between glycemic control and short- to long-term outcomes in coronavirus disease 2019 (COVID-19) patients with type 2 diabetes (T2D). DESIGN AND METHODS: A multi-center prospective cohort study including 574 COVID-19 patients with T2D was conducted in Wuhan, China. All patients were followed-up 1 year after hospital discharge using a uniformed questionnaire including self-reported symptoms, and the chronic obstructive pulmonary disease assessment test items. RESULTS: Of the 574 patients, 443 (77.2%) had well-controlled blood glucose. Glycemic control was significantly associated with decreased risk of death [odds ratio (OR) 0.24, 95% confidence interval (CI) 0.10-0.57], intensive care unit admission (OR 0.22, 95% CI 0.10-0.49), invasive mechanical ventilation (OR 0.25, 95% CI 0.08-0.72), disease progression (OR 0.25, 95% CI 0.11-0.55), and composite outcome (OR 0.26, 95% CI 0.14-0.49). The top five long-term sequelae include fatigue (31.5%), sweating (21.2%), chest tightness (15.1%), anxiety (12.2%), myalgia (10.6%) and short breath (6.4%). Glycemic control was associated with decreased risk of respiratory sequelae (OR 0.42, 95% CI 0.18-0.99; P = 0.048). CONCLUSIONS: Glycemic control was significantly associated with short-term outcomes in COVID-19 patients with T2D and showed a significant association with long-term respiratory sequelae. The management and control of blood glucose has a positive impact on prognosis of COVID-19.
Authors: Krisztina Kupai; Tamás Várkonyi; Szilvia Török; Viktória Gáti; Zsolt Czimmerer; László G Puskás; Gábor J Szebeni Journal: Life (Basel) Date: 2022-08-08