Uttpal Anand1, M Carpena2, Monika Kowalska-Góralska3, P Garcia-Perez4, Kumari Sunita5, Elza Bontempi6, Abhijit Dey7, Miguel A Prieto8, Jarosław Proćków9, Jesus Simal-Gandara10. 1. Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel. Electronic address: ushuats@gmail.com. 2. Universidade de Vigo, Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Faculty of Science, E32004 Ourense, Spain. Electronic address: mcarpena@uvigo.es. 3. Department of Limnology and Fisheries, Institute of Animal Husbandry and Breeding, Wrocław University of Environmental and Life Sciences, 50-375 Wrocław, Poland. Electronic address: monika.kowalska-goralska@upwr.edu.pl. 4. Universidade de Vigo, Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Faculty of Science, E32004 Ourense, Spain. Electronic address: pasgarcia@uvigo.es. 5. Department of Botany, Deen Dayal Upadhyay Gorakhpur University, Gorakhpur, Uttar Pradesh 273009, India. 6. INSTM and Chemistry for Technologies Laboratory, Department of Mechanical and Industrial Engineering, University of Brescia, Via Branze, 38, 25123 Brescia, Italy. Electronic address: elza.bontempi@unibs.it. 7. Department of Life Sciences, Presidency University, 86/1 College Street, Kolkata, 700073, West Bengal, India. Electronic address: abhijit.dbs@presiuniv.ac.in. 8. Universidade de Vigo, Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Faculty of Science, E32004 Ourense, Spain. Electronic address: mprieto@uvigo.es. 9. Department of Plant Biology, Institute of Environmental Biology, Wrocław University of Environmental and Life Sciences, ul. Kożuchowska 7a, 51-631 Wrocław, Poland. Electronic address: jaroslaw.prockow@upwr.edu.pl. 10. Universidade de Vigo, Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Faculty of Science, E32004 Ourense, Spain. Electronic address: jsimal@uvigo.es.
Abstract
BACKGROUND: Antibiotic resistance is one of the current threats to human health, forcing the use of drugs that are more noxious, costlier, and with low efficiency. There are several causes behind antibiotic resistance, including over-prescription of antibiotics in both humans and livestock. In this scenario, researchers are shifting to new alternatives to fight back this concerning situation. SCOPE AND APPROACH: Nanoparticles have emerged as new tools that can be used to combat deadly bacterial infections directly or indirectly to overcome antibiotic resistance. Although nanoparticles are being used in the pharmaceutical industry, there is a constant concern about their toxicity toward human health because of the involvement of well-known toxic chemicals (i.e., sodium/potassium borohydride) making their use very risky for eukaryotic cells. KEY FINDINGS AND CONCLUSIONS: Multiple nanoparticle-based approaches to counter bacterial infections, providing crucial insight into the design of elements that play critical roles in the creation of antimicrobial nanotherapeutic drugs, are currently underway. In this context, plant-based nanoparticles will be less toxic than many other forms, which constitute promising candidates to avoid widespread damage to the microbiome associated with current practices. This article aims to review the actual knowledge on plant-based nanoparticle products for antibiotic resistance and the possible replacement of antibiotics to treat multidrug-resistant bacterial infections.
BACKGROUND: Antibiotic resistance is one of the current threats to human health, forcing the use of drugs that are more noxious, costlier, and with low efficiency. There are several causes behind antibiotic resistance, including over-prescription of antibiotics in both humans and livestock. In this scenario, researchers are shifting to new alternatives to fight back this concerning situation. SCOPE AND APPROACH: Nanoparticles have emerged as new tools that can be used to combat deadly bacterial infections directly or indirectly to overcome antibiotic resistance. Although nanoparticles are being used in the pharmaceutical industry, there is a constant concern about their toxicity toward human health because of the involvement of well-known toxic chemicals (i.e., sodium/potassium borohydride) making their use very risky for eukaryotic cells. KEY FINDINGS AND CONCLUSIONS: Multiple nanoparticle-based approaches to counter bacterial infections, providing crucial insight into the design of elements that play critical roles in the creation of antimicrobial nanotherapeutic drugs, are currently underway. In this context, plant-based nanoparticles will be less toxic than many other forms, which constitute promising candidates to avoid widespread damage to the microbiome associated with current practices. This article aims to review the actual knowledge on plant-based nanoparticle products for antibiotic resistance and the possible replacement of antibiotics to treat multidrug-resistant bacterial infections.
Keywords:
Antibiotic-resistant bacteria (ARB); Environmental and health impact; Global economies and public health; Nanoparticles and their applications; Nanoparticles toxicity/nanotoxicology; Plant-derived nanoparticles
Authors: Samuel O Asiedu; Priscilla Kini; Bill C Aglomasa; Emmanuel K A Amewu; Ebenezer Asiedu; Solomon Wireko; Kennedy G Boahen; Afiat Berbudi; Augustina A Sylverken; Alexander Kwarteng Journal: Health Sci Rep Date: 2022-07-20
Authors: José M Pérez de la Lastra; Uttpal Anand; Sergio González-Acosta; Manuel R López; Abhijit Dey; Elza Bontempi; Antonio Morales delaNuez Journal: Front Immunol Date: 2022-06-02 Impact factor: 8.786