Jenna A Chiang1,2, Paulina T Feghali1,2, Anita Saavedra1,2, Ashley M Whitaker3,4. 1. Cancer and Blood Disease Institute, Children's Hospital Los Angeles (CHLA), Los Angeles, CA, USA. 2. Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. 3. Cancer and Blood Disease Institute, Children's Hospital Los Angeles (CHLA), Los Angeles, CA, USA. awhitaker@chla.usc.edu. 4. Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. awhitaker@chla.usc.edu.
Abstract
PURPOSE: While the effects of sleep on cognition in typically developing children are well established, there is a paucity of research in patients with pediatric brain tumor (PBT), despite their increased risk for sleep-related disturbances. The aim of this retrospective study was to examine the impact of sleep factors on patient-reported outcome (PRO) measures, including adaptive and executive functioning within this population. METHODS: 133 patients with PBT (52% male) ages 5-23 (x̄ = 12.8 years; SD = 4.5 years) underwent neuropsychological evaluation, including assessment of adaptive and executive functioning. Subjective sleep concerns, nocturnal sleep duration, and daytime sleep behavior were also collected and compared to age-based guidelines. RESULTS: Nearly 30% of patients endorsed subjective sleep concerns, while the sample as a whole reported reduced nocturnal sleep duration (approximately one hour below age-based recommendations). Despite the expectation for monophasic sleep by age five, nearly half of the sample reported consistent daytime napping. Inadequate sleep predicted decreased adaptive functioning, F(1, 56) = 4.23, p = .022 (R2 = .07), as well as increased symptoms of executive dysfunction, F(1, 108) = 3.51, p = .003 (R2 = .03). CONCLUSION: Patients with PBT demonstrate several aspects of abnormal sleep, which are associated with poorer long-term PROs. Further exploration of diagnostic, treatment-related, and demographic variables will be needed to better understand these relationships among patients with PBT in order to inform appropriate interventions.
PURPOSE: While the effects of sleep on cognition in typically developing children are well established, there is a paucity of research in patients with pediatric brain tumor (PBT), despite their increased risk for sleep-related disturbances. The aim of this retrospective study was to examine the impact of sleep factors on patient-reported outcome (PRO) measures, including adaptive and executive functioning within this population. METHODS: 133 patients with PBT (52% male) ages 5-23 (x̄ = 12.8 years; SD = 4.5 years) underwent neuropsychological evaluation, including assessment of adaptive and executive functioning. Subjective sleep concerns, nocturnal sleep duration, and daytime sleep behavior were also collected and compared to age-based guidelines. RESULTS: Nearly 30% of patients endorsed subjective sleep concerns, while the sample as a whole reported reduced nocturnal sleep duration (approximately one hour below age-based recommendations). Despite the expectation for monophasic sleep by age five, nearly half of the sample reported consistent daytime napping. Inadequate sleep predicted decreased adaptive functioning, F(1, 56) = 4.23, p = .022 (R2 = .07), as well as increased symptoms of executive dysfunction, F(1, 108) = 3.51, p = .003 (R2 = .03). CONCLUSION: Patients with PBT demonstrate several aspects of abnormal sleep, which are associated with poorer long-term PROs. Further exploration of diagnostic, treatment-related, and demographic variables will be needed to better understand these relationships among patients with PBT in order to inform appropriate interventions.
Authors: Jean-Philippe Chaput; Casey E Gray; Veronica J Poitras; Valerie Carson; Reut Gruber; Timothy Olds; Shelly K Weiss; Sarah Connor Gorber; Michelle E Kho; Margaret Sampson; Kevin Belanger; Sheniz Eryuzlu; Laura Callender; Mark S Tremblay Journal: Appl Physiol Nutr Metab Date: 2016-06 Impact factor: 2.665