Carlos Heriberto Orces1. 1. Laredo Medical Center-Medicine, 1700 E Saunders St, Laredo, TX, 78041, USA. corces07@yahoo.com.
Abstract
BACKGROUND: The mutation of the mouse klotho gene leads to a syndrome resembling aging including calcification of the aorta. OBJECTIVE: To examine the relationship between serum soluble klotho levels and abdominal aorta calcification (AAC) in subjects aged 60-79 years. METHODS: The National Health and Nutrition Examination Survey data were analyzed using logistic regression models to examine the independent association between soluble klotho tertile levels and the Kauppila AAC-24 score. RESULTS: A total of 1042 participants with a median klotho level of 796 pg/ml comprised the study sample. Overall, the prevalence of AAC was 39.2% and severe AAC was seen in 15.6% subjects. Participants with klotho levels ≤ 700 pg/ml were twice as likely (OR 2.21 (95% CI 1.15-4.26) to have severe AAC than their counterparts with klotho levels ≥ 906 pg/ml. CONCLUSIONS: Soluble klotho levels were inversely associated with severe AAC in older adults.
BACKGROUND: The mutation of the mouse klotho gene leads to a syndrome resembling aging including calcification of the aorta. OBJECTIVE: To examine the relationship between serum soluble klotho levels and abdominal aorta calcification (AAC) in subjects aged 60-79 years. METHODS: The National Health and Nutrition Examination Survey data were analyzed using logistic regression models to examine the independent association between soluble klotho tertile levels and the Kauppila AAC-24 score. RESULTS: A total of 1042 participants with a median klotho level of 796 pg/ml comprised the study sample. Overall, the prevalence of AAC was 39.2% and severe AAC was seen in 15.6% subjects. Participants with klotho levels ≤ 700 pg/ml were twice as likely (OR 2.21 (95% CI 1.15-4.26) to have severe AAC than their counterparts with klotho levels ≥ 906 pg/ml. CONCLUSIONS: Soluble klotho levels were inversely associated with severe AAC in older adults.
Authors: Frederico Bastos Gonçalves; Michiel T Voûte; Sanne E Hoeks; Michel B Chonchol; Eric E Boersma; Robert J Stolker; Hence J M Verhagen Journal: Heart Date: 2012-07 Impact factor: 5.994
Authors: Richard D Semba; Anne R Cappola; Kai Sun; Stefania Bandinelli; Mansi Dalal; Candace Crasto; Jack M Guralnik; Luigi Ferrucci Journal: J Am Geriatr Soc Date: 2011-08-24 Impact factor: 5.562
Authors: M Kuro-o; Y Matsumura; H Aizawa; H Kawaguchi; T Suga; T Utsugi; Y Ohyama; M Kurabayashi; T Kaname; E Kume; H Iwasaki; A Iida; T Shiraki-Iida; S Nishikawa; R Nagai; Y I Nabeshima Journal: Nature Date: 1997-11-06 Impact factor: 49.962
Authors: Joshua R Lewis; John T Schousboe; Wai H Lim; Germaine Wong; Kun Zhu; Ee M Lim; Kevin E Wilson; Peter L Thompson; Douglas P Kiel; Richard L Prince Journal: Arterioscler Thromb Vasc Biol Date: 2015-11-24 Impact factor: 8.311
Authors: Javier Donate-Correa; Carla M Ferri; Ernesto Martín-Núñez; Nayra Pérez-Delgado; Ainhoa González-Luis; Carmen Mora-Fernández; Juan F Navarro-González Journal: Sci Rep Date: 2021-08-05 Impact factor: 4.379